ENSG00000085733


Homo sapiens

Features
Gene ID: ENSG00000085733
  
Biological name :CTTN
  
Synonyms : cortactin / CTTN / Q14247
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.3
Gene start: 70398404
Gene end: 70436584
  
Corresponding Affymetrix probe sets: 1567277_at (Human Genome U133 Plus 2.0 Array)   201059_at (Human Genome U133 Plus 2.0 Array)   214073_at (Human Genome U133 Plus 2.0 Array)   214074_s_at (Human Genome U133 Plus 2.0 Array)   214782_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000301843
Ensembl peptide - ENSP00000365745
Ensembl peptide - ENSP00000431421
Ensembl peptide - ENSP00000436613
Ensembl peptide - ENSP00000317189
NCBI entrez gene - 2017     See in Manteia.
OMIM - 164765
RefSeq - XM_006718448
RefSeq - NM_001184740
RefSeq - NM_005231
RefSeq - NM_138565
RefSeq - XM_006718447
RefSeq Peptide - NP_005222
RefSeq Peptide - NP_612632
RefSeq Peptide - NP_001171669
swissprot - Q14247
swissprot - H0YCD9
swissprot - A0A024R5M3
swissprot - H0YEV2
Ensembl - ENSG00000085733
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cttnENSDARG00000011777Danio rerio
 CTTNENSGALG00000007700Gallus gallus
 CttnENSMUSG00000031078Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCLS1 / P14317 / hematopoietic cell-specific Lyn substrate 1ENSG0000018035335
DBNL / Q9UJU6 / drebrin likeENSG0000013627915
DBN1 / Q16643 / drebrin 1ENSG0000011375811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003134  Hs1/Cortactin
 IPR015503  Cortactin
 IPR035716  Cortactin, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IEA
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030516 regulation of axon extension ISS
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031532 actin cytoskeleton reorganization ISS
 biological_processGO:0045987 positive regulation of smooth muscle contraction IMP
 biological_processGO:0048041 focal adhesion assembly ISS
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0048870 cell motility ISS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0097062 dendritic spine maintenance IEA
 biological_processGO:0097581 lamellipodium organization ISS
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit ISS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0030863 cortical cytoskeleton IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005522 profilin binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PAKs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction






 

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