ENSG00000180353


Homo sapiens

Features
Gene ID: ENSG00000180353
  
Biological name :HCLS1
  
Synonyms : HCLS1 / hematopoietic cell-specific Lyn substrate 1 / P14317
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q13.33
Gene start: 121631399
Gene end: 121660927
  
Corresponding Affymetrix probe sets: 202957_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418299
Ensembl peptide - ENSP00000420507
Ensembl peptide - ENSP00000419614
Ensembl peptide - ENSP00000320176
Ensembl peptide - ENSP00000387645
NCBI entrez gene - 3059     See in Manteia.
OMIM - 601306
RefSeq - NM_005335
RefSeq - NM_001292041
RefSeq Peptide - NP_001278970
RefSeq Peptide - NP_005326
swissprot - P14317
swissprot - F8WDD5
swissprot - F8WEZ6
swissprot - E7EVW7
Ensembl - ENSG00000180353
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcls1ENSDARG00000012729Danio rerio
 HCLS1ENSGALG00000039682Gallus gallus
 Hcls1ENSMUSG00000022831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTTN / Q14247 / cortactinENSG0000008573345
DBNL / Q9UJU6 / drebrin likeENSG0000013627920
DBN1 / Q16643 / drebrin 1ENSG0000011375814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR003134  Hs1/Cortactin
 IPR028534  Hematopoietic lineage cell-specific protein
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0030041 actin filament polymerization IEA
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030833 regulation of actin filament polymerization IMP
 biological_processGO:0030854 positive regulation of granulocyte differentiation IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IMP
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0071345 cellular response to cytokine stimulus IMP
 biological_processGO:2000107 negative regulation of leukocyte apoptotic process IMP
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IC
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr