ENSG00000136279


Homo sapiens

Features
Gene ID: ENSG00000136279
  
Biological name :DBNL
  
Synonyms : DBNL / drebrin like / Q9UJU6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p13
Gene start: 44044640
Gene end: 44069456
  
Corresponding Affymetrix probe sets: 222429_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418978
Ensembl peptide - ENSP00000418301
Ensembl peptide - ENSP00000419992
Ensembl peptide - ENSP00000390397
Ensembl peptide - ENSP00000392113
Ensembl peptide - ENSP00000397855
Ensembl peptide - ENSP00000398931
Ensembl peptide - ENSP00000400817
Ensembl peptide - ENSP00000403372
Ensembl peptide - ENSP00000405343
Ensembl peptide - ENSP00000410681
Ensembl peptide - ENSP00000411701
Ensembl peptide - ENSP00000415173
Ensembl peptide - ENSP00000415395
Ensembl peptide - ENSP00000416421
Ensembl peptide - ENSP00000417653
Ensembl peptide - ENSP00000417749
Ensembl peptide - ENSP00000418006
NCBI entrez gene - 28988     See in Manteia.
OMIM - 610106
RefSeq - NM_001122956
RefSeq - NM_001014436
RefSeq - NM_001284313
RefSeq - NM_001284315
RefSeq - NM_014063
RefSeq - XM_011515325
RefSeq Peptide - NP_001271244
RefSeq Peptide - NP_054782
RefSeq Peptide - NP_001271242
RefSeq Peptide - NP_001014436
RefSeq Peptide - NP_001116428
swissprot - B4DDD6
swissprot - Q9UJU6
swissprot - F2Z2V3
swissprot - F2Z3E3
swissprot - F8WB73
swissprot - F8WBB2
swissprot - F8WC20
swissprot - F8WBG8
swissprot - F8WCK3
swissprot - F8WFE1
swissprot - H0Y5J4
swissprot - H7C111
Ensembl - ENSG00000136279
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbnlaENSDARG00000008170Danio rerio
 dbnlbENSDARG00000016016Danio rerio
 DbnlENSMUSG00000020476Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DBN1 / Q16643 / drebrin 1ENSG0000011375832
HCLS1 / P14317 / hematopoietic cell-specific Lyn substrate 1ENSG0000018035323
CTTN / Q14247 / cortactinENSG0000008573322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002108  Actin-depolymerising factor homology domain
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR029923  Drebrin-like protein
 IPR035717  Drebrin-like protein, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0007416 synapse assembly ISS
 biological_processGO:0016601 Rac protein signal transduction ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0071800 podosome assembly ISS
 biological_processGO:0097178 ruffle assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0002102 podosome ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
Caspase-mediated cleavage of cytoskeletal proteins
Neurexins and neuroligins
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082458 DLG3 / Q92796 / discs large MAGUK scaffold protein 3  / reaction / complex
 ENSG00000116544 DLGAP3 / O95886 / DLG associated protein 3  / complex / reaction
 ENSG00000150672 DLG2 / Q15700 / discs large MAGUK scaffold protein 2  / reaction / complex
 ENSG00000161681 Q9Y566 / SHANK1 / SH3 and multiple ankyrin repeat domains 1  / complex / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / complex / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000170579 DLGAP1 / O14490 / DLG associated protein 1  / reaction / complex
 ENSG00000080845 DLGAP4 / Q9Y2H0 / DLG associated protein 4  / complex / reaction
 ENSG00000162105 Q9UPX8 / SHANK2 / SH3 and multiple ankyrin repeat domains 2  / complex / reaction
 ENSG00000198010 DLGAP2 / Q9P1A6 / DLG associated protein 2  / reaction / complex






 

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