ENSMUSG00000031284


Mus musculus

Features
Gene ID: ENSMUSG00000031284
  
Biological name :Pak3
  
Synonyms : Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3
  
Possible biological names infered from orthology : O75914 / p21 (RAC1) activated kinase 3
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F2
Gene start: 143518591
Gene end: 143797796
  
Corresponding Affymetrix probe sets: 10602198 (MoGene1.0st)   1417923_at (Mouse Genome 430 2.0 Array)   1417924_at (Mouse Genome 430 2.0 Array)   1435486_at (Mouse Genome 430 2.0 Array)   1437318_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118549
Ensembl peptide - ENSMUSP00000114352
Ensembl peptide - ENSMUSP00000118716
Ensembl peptide - ENSMUSP00000126562
Ensembl peptide - ENSMUSP00000119090
Ensembl peptide - ENSMUSP00000033640
Ensembl peptide - ENSMUSP00000108484
Ensembl peptide - ENSMUSP00000108485
Ensembl peptide - ENSMUSP00000108486
Ensembl peptide - ENSMUSP00000108489
NCBI entrez gene - 18481     See in Manteia.
MGI - MGI:1339656
RefSeq - XM_017318423
RefSeq - XM_006528752
RefSeq - XM_006528753
RefSeq - XM_006528754
RefSeq - XM_011247790
RefSeq - XM_017318417
RefSeq - XM_017318418
RefSeq - XM_017318419
RefSeq - XM_017318420
RefSeq - XM_017318421
RefSeq - XM_017318422
RefSeq - NM_001195046
RefSeq - NM_001195047
RefSeq - NM_001195048
RefSeq - NM_001195049
RefSeq - NM_008778
RefSeq - XM_006528747
RefSeq Peptide - NP_001181976
RefSeq Peptide - NP_001181977
RefSeq Peptide - NP_001181978
RefSeq Peptide - NP_032804
RefSeq Peptide - NP_001181975
swissprot - A3KGC5
swissprot - A3KGC4
swissprot - A3KGC3
swissprot - Q61036
swissprot - A3KGC2
Ensembl - ENSMUSG00000031284
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK3ENSGALG00000008058Gallus gallus
 PAK3ENSG00000077264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*ENSMUSG0000003077479
Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*ENSMUSG0000002278173
Pak7 / Q8C015 / Serine/threonine-protein kinase PAK 5 / PAK5* / Q9P286* / p21 (RAC1) activated kinase 5*ENSMUSG0000003991336
Pak4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4 / O96013* / p21 (RAC1) activated kinase 4*ENSMUSG0000003060235
Pak6 / Q3ULB5 / Serine/threonine-protein kinase PAK 6 / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSMUSG0000007492334
Taok1 / Q5F2E8 / TAO kinase 1 / Q7L7X3*ENSMUSG0000001729123
Taok2 / Q6ZQ29 / Serine/threonine-protein kinase TAO2 / Q9UL54* / TAO kinase 2*ENSMUSG0000005998122
Taok3 / Q8BYC6 / TAO kinase 3 / Q9H2K8*ENSMUSG0000006128821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035063  p21-activated kinase 3, catalytic domain
 IPR035065  Serine/threonine-protein kinase PAK2/3
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0030833 regulation of actin filament polymerization ISS
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0050770 regulation of axonogenesis IBA
 biological_processGO:0060996 dendritic spine development IGI
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004708 MAP kinase kinase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Pitx2tm2Sac/Pitx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pitx2tm2Sac/Pitx2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / complex / reaction
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / reaction / complex
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction
 ENSMUSG00000101645 P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*  / reaction
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000031078 Cttn / Q60598 / cortactin / Q14247*  / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex / reaction
 ENSMUSG00000031871 Cdh5 / P55284 / Cadherin-5 / P33151*  / reaction
 ENSMUSG00000001552 Jup / Q02257 / Junction plakoglobin / P14923*  / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000029674 Limk1 / P53668 / LIM domain kinase 1 / P53667*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000024558 Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*  / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction






 

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