ENSMUSG00000024558


Mus musculus

Features
Gene ID: ENSMUSG00000024558
  
Biological name :Mapk4
  
Synonyms : Mapk4 / Mitogen-activated protein kinase 4 / Q6P5G0
  
Possible biological names infered from orthology : P31152
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 73928486
Gene end: 74065359
  
Corresponding Affymetrix probe sets: 10459747 (MoGene1.0st)   1435367_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123922
Ensembl peptide - ENSMUSP00000124408
Ensembl peptide - ENSMUSP00000089462
NCBI entrez gene - 225724     See in Manteia.
MGI - MGI:2444559
RefSeq - XM_006525900
RefSeq - XM_006525901
RefSeq - XM_017317891
RefSeq - NM_172632
RefSeq Peptide - NP_766220
swissprot - Q6P5G0
swissprot - E9PXX5
swissprot - E9Q3I6
Ensembl - ENSMUSG00000024558
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk4ENSDARG00000110581Danio rerio
 MAPK4ENSG00000141639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*ENSMUSG0000004268856
Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*ENSMUSG0000000103425
Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*ENSMUSG0000006306524
Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*ENSMUSG0000006335824
Mapk15 / Q80Y86 / Mitogen-activated protein kinase 15 / Q8TD08*ENSMUSG0000006370423
Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*ENSMUSG0000001737620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008350  Mitogen-activated protein (MAP) kinase, ERK3/4
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0071310 cellular response to organic substance IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk4tm1Melo/Mapk4tm1Melo,Mapk6tm1Melo/Mapk6tm1Melo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mapk4tm1Melo/Mapk4tm1Melo,Mapk6tm1Melo/Mapk6tm1Melo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / reaction / complex






 

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