ENSMUSG00000042688


Mus musculus

Features
Gene ID: ENSMUSG00000042688
  
Biological name :Mapk6
  
Synonyms : Mapk6 / Mitogen-activated protein kinase 6 / Q61532
  
Possible biological names infered from orthology : Q16659
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 75369062
Gene end: 75410005
  
Corresponding Affymetrix probe sets: 10594988 (MoGene1.0st)   1419168_at (Mouse Genome 430 2.0 Array)   1419169_at (Mouse Genome 430 2.0 Array)   1429963_at (Mouse Genome 430 2.0 Array)   1459146_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040315
Ensembl peptide - ENSMUSP00000129024
NCBI entrez gene - 50772     See in Manteia.
MGI - MGI:1354946
RefSeq - XM_011242767
RefSeq - NM_015806
RefSeq - NM_027418
RefSeq Peptide - NP_081694
RefSeq Peptide - NP_056621
swissprot - Q61532
Ensembl - ENSMUSG00000042688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk6ENSDARG00000032103Danio rerio
 MAPK6ENSGALG00000031448Gallus gallus
 MAPK6ENSG00000069956Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*ENSMUSG0000002455845
Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*ENSMUSG0000000103424
Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*ENSMUSG0000006335821
Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*ENSMUSG0000006306521
Mapk15 / Q80Y86 / Mitogen-activated protein kinase 15 / Q8TD08*ENSMUSG0000006370421
Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*ENSMUSG0000001737617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008350  Mitogen-activated protein (MAP) kinase, ERK3/4
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IGI
 biological_processGO:0071310 cellular response to organic substance IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032156 septin cytoskeleton IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0005162 carpoptosis "paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:81738]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Mapk4tm1Melo/Mapk4tm1Melo,Mapk6tm1Melo/Mapk6tm1Melo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Ptpn11tm1.1Wbm/Ptpn11tm1.1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Mapk4tm1Melo/Mapk4tm1Melo,Mapk6tm1Melo/Mapk6tm1Melo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000033102 Cdc14b / Q6PFY9 / Dual specificity protein phosphatase CDC14B / O60729* / cell division cycle 14B*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000063838 Q9Z0X0 / 1700027J19Rik / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / CDC42EP5* / CDC42 effector protein 5*  / reaction
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction
 ENSMUSG00000034165 Ccnd3 / P30282 / G1/S-specific cyclin-D3 / P30281* / cyclin D3*  / reaction / complex
 ENSMUSG00000001833 Sept7 / septin-7 isoform 2 / Q16181* / septin 7*  / reaction / complex
 ENSMUSG00000036533 Q9CQC5 / Cdc42ep3 / Cdc42 effector protein 3 / Q9UKI2*  / reaction
 ENSMUSG00000045664 Q8JZX9 / Cdc42ep2 / Cdc42 effector protein 2 / O14613*  / reaction
 ENSMUSG00000029454 O54992 / Mapkapk5 / MAP kinase-activated protein kinase 5 / Q8IW41* / mitogen-activated protein kinase-activated protein kinase 5*  / complex / reaction
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / complex / reaction
 ENSMUSG00000033502 Cdc14a / Q6GQT0 / Dual specificity protein phosphatase CDC14A / Q9UNH5* / cell division cycle 14A*  / complex / reaction






 

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