ENSMUSG00000033102


Mus musculus

Features
Gene ID: ENSMUSG00000033102
  
Biological name :Cdc14b
  
Synonyms : Cdc14b / Dual specificity protein phosphatase CDC14B / Q6PFY9
  
Possible biological names infered from orthology : cell division cycle 14B / O60729
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B3
Gene start: 64189268
Gene end: 64275290
  
Corresponding Affymetrix probe sets: 10410099 (MoGene1.0st)   1429418_at (Mouse Genome 430 2.0 Array)   1437070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152246
Ensembl peptide - ENSMUSP00000152870
Ensembl peptide - ENSMUSP00000152843
Ensembl peptide - ENSMUSP00000152736
Ensembl peptide - ENSMUSP00000152388
Ensembl peptide - ENSMUSP00000046003
Ensembl peptide - ENSMUSP00000105391
Ensembl peptide - ENSMUSP00000105392
NCBI entrez gene - 218294     See in Manteia.
MGI - MGI:2441808
RefSeq - XM_011244515
RefSeq - XM_006517229
RefSeq - XM_006517219
RefSeq - NM_001122989
RefSeq - NM_172587
RefSeq - XM_006517227
RefSeq Peptide - NP_001116461
RefSeq Peptide - NP_766175
swissprot - Q6PFY9
swissprot - A0A1Y7VKG2
swissprot - A0A1Y7VJ26
swissprot - A0A1Y7VJB9
swissprot - A0A1Y7VK12
Ensembl - ENSMUSG00000033102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc14bENSDARG00000021483Danio rerio
 CDC14BENSGALG00000012627Gallus gallus
 CDC14BENSG00000081377Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc14a / Q6GQT0 / Dual specificity protein phosphatase CDC14A / Q9UNH5* / cell division cycle 14A*ENSMUSG0000003350251
Dusp23 / Q6NT99 / Dual specificity protein phosphatase 23 / Q9BVJ7* / dual specificity phosphatase 23*ENSMUSG000000265447


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029260  Dual specificity/tyrosine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006470 protein dephosphorylation ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007096 regulation of exit from mitosis IBA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051256 mitotic spindle midzone assembly IBA
 biological_processGO:0060271 cilium assembly IBA
 biological_processGO:0071850 mitotic cell cycle arrest IBA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISO
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity ISS
 cellular_componentGO:0000922 spindle pole IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IBA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oprm1tm1Lex/Oprm1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr