ENSG00000081377


Homo sapiens

Features
Gene ID: ENSG00000081377
  
Biological name :CDC14B
  
Synonyms : CDC14B / cell division cycle 14B / O60729
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q22.33
Gene start: 96490241
Gene end: 96619830
  
Corresponding Affymetrix probe sets: 208022_s_at (Human Genome U133 Plus 2.0 Array)   211347_at (Human Genome U133 Plus 2.0 Array)   211348_s_at (Human Genome U133 Plus 2.0 Array)   221555_x_at (Human Genome U133 Plus 2.0 Array)   221556_at (Human Genome U133 Plus 2.0 Array)   230887_at (Human Genome U133 Plus 2.0 Array)   234605_at (Human Genome U133 Plus 2.0 Array)   234740_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420572
Ensembl peptide - ENSP00000413940
Ensembl peptide - ENSP00000417897
Ensembl peptide - ENSP00000364388
Ensembl peptide - ENSP00000364389
Ensembl peptide - ENSP00000364390
Ensembl peptide - ENSP00000396951
Ensembl peptide - ENSP00000400480
NCBI entrez gene - 8555     See in Manteia.
OMIM - 603505
RefSeq - XM_017015249
RefSeq - XM_017015241
RefSeq - XM_017015242
RefSeq - XM_017015243
RefSeq - XM_017015244
RefSeq - XM_017015245
RefSeq - XM_017015246
RefSeq - XM_017015247
RefSeq - XM_017015248
RefSeq - NM_001077181
RefSeq - NM_003671
RefSeq - NM_033331
RefSeq - XM_005252288
RefSeq - XM_011519147
RefSeq - XM_011519148
RefSeq - XM_011519149
RefSeq - XM_011519150
RefSeq - XM_011519151
RefSeq - XM_011519152
RefSeq - XM_011519153
RefSeq - XM_011519156
RefSeq - XM_011519158
RefSeq - XM_011519159
RefSeq - XM_017015240
RefSeq Peptide - NP_201588
RefSeq Peptide - NP_001070649
RefSeq Peptide - NP_001338496
RefSeq Peptide - NP_003662
swissprot - H7C3U8
swissprot - O60729
swissprot - Q5JU07
swissprot - H0Y577
Ensembl - ENSG00000081377
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc14bENSDARG00000021483Danio rerio
 CDC14BENSGALG00000012627Gallus gallus
 Cdc14bENSMUSG00000033102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC14A / Q9UNH5 / cell division cycle 14AENSG0000007933553
DUSP23 / Q9BVJ7 / dual specificity phosphatase 23ENSG000001587168


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029260  Dual specificity/tyrosine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006470 protein dephosphorylation NAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007096 regulation of exit from mitosis IBA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051256 mitotic spindle midzone assembly IBA
 biological_processGO:0060271 cilium assembly IBA
 biological_processGO:0071850 mitotic cell cycle arrest IBA
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IDA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IMP
 cellular_componentGO:0000922 spindle pole IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / complex / reaction






 

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