ENSG00000079335


Homo sapiens

Features
Gene ID: ENSG00000079335
  
Biological name :CDC14A
  
Synonyms : CDC14A / cell division cycle 14A / Q9UNH5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p21.2
Gene start: 100345001
Gene end: 100520278
  
Corresponding Affymetrix probe sets: 205288_at (Human Genome U133 Plus 2.0 Array)   210440_s_at (Human Genome U133 Plus 2.0 Array)   210441_at (Human Genome U133 Plus 2.0 Array)   210742_at (Human Genome U133 Plus 2.0 Array)   210743_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495617
Ensembl peptide - ENSP00000494661
Ensembl peptide - ENSP00000496153
Ensembl peptide - ENSP00000496374
Ensembl peptide - ENSP00000336739
Ensembl peptide - ENSP00000354916
Ensembl peptide - ENSP00000359142
Ensembl peptide - ENSP00000388501
Ensembl peptide - ENSP00000489217
Ensembl peptide - ENSP00000493651
Ensembl peptide - ENSP00000494417
Ensembl peptide - ENSP00000494551
NCBI entrez gene - 8556     See in Manteia.
OMIM - 603504
RefSeq - XM_017002647
RefSeq - NM_033312
RefSeq - NM_033313
RefSeq - XM_005271294
RefSeq - XM_005271296
RefSeq - XM_011542340
RefSeq - XM_011542341
RefSeq - XM_011542345
RefSeq - XM_011542346
RefSeq - XM_017002646
RefSeq - NM_001319210
RefSeq - NM_001319211
RefSeq - NM_001319212
RefSeq - NM_003672
RefSeq Peptide - NP_001306140
RefSeq Peptide - NP_001306141
RefSeq Peptide - NP_003663
RefSeq Peptide - NP_201569
RefSeq Peptide - NP_201570
RefSeq Peptide - NP_001306139
swissprot - A0A0U1RQX7
swissprot - C9JSP6
swissprot - Q9UNH5
Ensembl - ENSG00000079335
  
Related genetic diseases (OMIM): 616958 - Deafness, autosomal recessive 105, 616958
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc14aaENSDARG00000013858Danio rerio
 cdc14abENSDARG00000057016Danio rerio
 CDC14AENSGALG00000005248Gallus gallus
 Cdc14aENSMUSG00000033502Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC14B / O60729 / cell division cycle 14BENSG0000008137742
DUSP23 / Q9BVJ7 / dual specificity phosphatase 23ENSG000001587166


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR026068  Dual specificity protein phosphatase CDC14A
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029260  Dual specificity/tyrosine protein phosphatase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007096 regulation of exit from mitosis IBA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051256 mitotic spindle midzone assembly IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060271 cilium assembly IBA
 biological_processGO:0071850 mitotic cell cycle arrest IBA
 cellular_componentGO:0000922 spindle pole IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0060091 kinocilium IEA
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr