| MP:0000003 | abnormal adipose tissue morphology | "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0000024 | lowered ear position | "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000186 | decreased circulating HDL cholesterol level | "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0000628 | abnormal mammary gland development | "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet
|
| MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0001140 | abnormal vaginal epithelium | "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001273 | decreased metastatic potential | |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0001289 | persistence of hyaloid capillary system | "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] |
Show
Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
|
| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0001431 | abnormal eating behavior | "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001780 | decreased brown fat amount | "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0001783 | decreased white fat amount | "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0001938 | delayed sexual maturation | "immaturity of the sexual organs at a given age" [J:61190] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002053 | decreased incidence of induced tumors | "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Myo18atm1b(KOMP)Wtsi/Myo18a+
Genetic Background: C57BL/6N-Myo18atm1b(KOMP)Wtsi/Ucd
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
|
| MP:0002310 | resistance to fatty liver development | "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002332 | abnormal exercise endurance | "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0002356 | abnormal spleen red pulp morphology | "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gabbr2tm1Bet/Gabbr2+
Genetic Background: BALB/c-Gabbr2tm1Bet
|
| MP:0002636 | delayed vaginal opening | "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0002644 | decreased circulating triglyceride level | "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002696 | decreased circulating glucagon level | "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0002702 | decreased circulating free fatty acid level | "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0002966 | decreased circulating alkaline phosphatase level | "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
|
| MP:0003084 | abnormal skeletal muscle fiber morphology | "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0003091 | abnormal cell migration | "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0003355 | reduced ovulation | "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0003620 | decreased urine output | "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0003699 | abnormal female reproductive system physiology | "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0003866 | abnormal defecation | "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0003953 | abnormal hormone level | "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0004701 | decreased circulating insulin-like growth factor I level | "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ncoa3tm2.2Jxu/Ncoa3tm2.2Jxu
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
|
| MP:0004702 | increased circulating insulin-like growth factor I level | "increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0004889 | increased energy expenditure | "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0004893 | decreased adiponectin level | "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005013 | increased lymphocyte number | "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005076 | abnormal cell differentiation | "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0005154 | increased B cell proliferation | "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005179 | decreased total circulating cholesterol level | "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005181 | decreased circulating estradiol level | "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
|
| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0005348 | increased T cell proliferation | "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005534 | decreased body temperature | "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6
|
| MP:0005659 | resistance to diet-induced obesity | "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0006094 | adipocyte hypertrophy | "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0006319 | abnormal epididymal fat pad | "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0008483 | increased spleen germinal center size | "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008658 | decreased interleukin-1 beta secretion | "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008735 | increased susceptibility to endotoxin shock | "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0008963 | increased carbon dioxide production | "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0008964 | decreased carbon dioxide production | "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0009006 | prolonged estrous cycle | "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0009116 | abnormal brown fat cell morphology | "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009125 | decreased brown fat cell lipid droplet size | "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009133 | decreased white fat cell size | "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009136 | decreased brown fat cell size | "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009289 | decreased epididymal fat pad weight | |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009341 | decreased splenocyte apoptosis | "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0009788 | increased susceptibility to bacterial infection induced morbidity/mortality | "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0010024 | increased total body fat amount | "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0010174 | decreased mammary gland epithelium proliferation | "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0010179 | rough coat | "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0010269 | decreased mammary gland tumor incidence | "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar
|
| MP:0010378 | increased respiratory quotient | "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0010400 | increased liver glycogen level | "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
|
| MP:0011049 | impaired adaptive thermogenesis | "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744] |
Show
Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H
|
| MP:0011630 | increased mitochondria size | "enlarged the cellular organelles responsible for energy production" [MGI:csmith] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0011708 | decreased fibroblast cell migration | "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac
|
| MP:0012106 | impaired exercise endurance | "impaired performance during controlled physical activity" [MGI:smb] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
Show
Allelic Composition: Ncoa3tm1Jxu/Ncoa3tm1Jxu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
|
