ENSDARG00000077404


Danio rerio

Features
Gene ID: ENSDARG00000077404
  
Biological name :ncoa3
  
Synonyms : ncoa3 / nuclear receptor coactivator 3
  
Possible biological names infered from orthology : Q9Y6Q9
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 18612166
Gene end: 18699569
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000142017
Ensembl peptide - ENSDARP00000102117
NCBI entrez gene - 564519     See in Manteia.
RefSeq - XM_687846
swissprot - F1QMV7
swissprot - A0A0R4IY58
ZFIN ID - ZDB-GENE-051107-8
Ensembl - ENSDARG00000077404
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCOA3ENSGALG00000004570Gallus gallus
 NCOA3ENSG00000124151Homo sapiens
 Ncoa3ENSMUSG00000027678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ncoa2 / nuclear receptor coactivator 2 / Q15596* / Q61026*ENSDARG0000001792937
ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*ENSDARG0000001825727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028818  Nuclear receptor coactivator 3
 IPR032565  Domain of unknown function DUF4927


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0016922 nuclear receptor binding IBA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018698 carm1 / Q6DC04 / coactivator-associated arginine methyltransferase 1 / Q9WVG6* / Q86X55* / Histone-arginine methyltransferase CARM1 *  / reaction / complex
 ENSDARG00000010246 prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / complex / reaction
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000032103 mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / reaction / complex
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex
 ENSDARG00000100940 nr5a2 / nuclear receptor subfamily 5, group A, member 2 / O00482*  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / complex
 ENSDARG00000105345 zgc:173552  / complex
 ENSDARG00000088123 znf217 / zinc finger protein 217 / O75362*  / complex






 

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