ENSDARG00000004111


Danio rerio

Features
Gene ID: ENSDARG00000004111
  
Biological name :esr1
  
Synonyms : esr1 / estrogen receptor 1
  
Possible biological names infered from orthology : Estrogen receptor / P03372 / P19785
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 26359756
Gene end: 26383375
  
Corresponding Affymetrix probe sets: Dr.10717.1.S1_at (Zebrafish Array)   Dr.10717.1.S2_at (Zebrafish Array)   NM_152959_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000082277
Ensembl peptide - ENSDARP00000152126
Ensembl peptide - ENSDARP00000131705
Ensembl peptide - ENSDARP00000024987
NCBI entrez gene - 259252     See in Manteia.
RefSeq - NM_152959
RefSeq - XM_009299438
RefSeq Peptide - NP_694491
swissprot - F1QL15
swissprot - A5PMH3
swissprot - A0A0R4ID06
ZFIN ID - ZDB-GENE-020806-5
Ensembl - ENSDARG00000004111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ESR1ENSGALG00000012973Gallus gallus
 ESR1ENSG00000091831Homo sapiens
 Esr1ENSMUSG00000019768Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000001645442
esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000003418142
esrrb / esrrga / estrogen-related receptor betaENSDARG0000000486127
esrrgb / estrogen-related receptor gamma bENSDARG0000001169627
esrrb / estrogen-related receptor beta / O95718*ENSDARG0000010084726
esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 *ENSDARG0000006926626
nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*ENSDARG0000002503221
nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*ENSDARG0000010208220
pgr / progesterone receptor / P06401* / Q00175*ENSDARG0000003596619
nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6*ENSDARG0000005585419
nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736*ENSDARG0000000079618
nr4a2a / nuclear receptor subfamily 4, group A, member 2a / NR4A2* / Q06219* / P43354* / nuclear receptor subfamily 4 group A member 2*ENSDARG0000001700718
ar / androgen receptor / P10275* / P19091*ENSDARG0000006797618
nr4a2b / nuclear receptor subfamily 4, group A, member 2bENSDARG0000004453218
FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSDARG0000011104314
esrrd / estrogen-related receptor deltaENSDARG0000001506412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001292  Oestrogen receptor
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR013088  Zinc finger, NHR/GATA-type
 IPR024178  Oestrogen receptor/oestrogen-related receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0030284 estrogen receptor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
PIP3 activates AKT signaling
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
RUNX1 regulates estrogen receptor mediated transcription
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium physical object quality , abnormal
posterior lateral line primordium decreased speed , abnormal
posterior lateral line primordium mislocalised , abnormal
Show

 ZFA:0005065 heart valve heart valve absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011462 otub1b / OTU deubiquitinase, ubiquitin aldehyde binding 1b / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex / reaction
 ENSDARG00000018698 carm1 / Q6DC04 / coactivator-associated arginine methyltransferase 1 / Q9WVG6* / Q86X55* / Histone-arginine methyltransferase CARM1 *  / reaction / complex
 ENSDARG00000006816 gtf2f2b / general transcription factor IIF, polypeptide 2b / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / complex
 ENSDARG00000007241 mycb / Q7ZVS9 / MYC proto-oncogene, bHLH transcription factor b / MYC* / Bmyc* / P01106* / P01108* / Q6P8Z1* / Protein B-Myc * / myelocytomatosis oncogene* / MYC proto-oncogene, bHLH transc...  / complex
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000034181 esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / complex / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000038835 ppid / peptidylprolyl isomerase D / Q08752* / Q9CR16* / peptidylprolyl isomerase D (cyclophilin D)*  / complex
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSDARG00000010246 prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000099675 kdm4b / lysine (K)-specific demethylase 4B / O94953* / Q91VY5* / lysine demethylase 4B* / Lysine-specific demethylase 4B *  / complex / reaction
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / reaction / complex
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000016454 esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *  / reaction / complex
 ENSDARG00000105345 zgc:173552  / reaction / complex
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / reaction / complex
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / complex / reaction
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / complex / reaction
 ENSDARG00000069910 gtf2f2a / general transcription factor IIF, polypeptide 2a / GTF2F2* / P13984* / Q8R0A0* / ral transcription factor IIF subunit 2 * / general transcription factor IIF subunit 2*  / complex
 ENSDARG00000070794 greb1 / growth regulation by estrogen in breast cancer 1 / Q3UHK3* / Q4ZG55* / Protein GREB1 *  / complex / reaction
 ENSDARG00000055536 otub1a / OTU deubiquitinase, ubiquitin aldehyde binding 1a / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / reaction / complex
 ENSDARG00000044811 cdk9 / cyclin-dependent kinase 9 (CDC2-related kinase) / P50750* / Q99J95* / cyclin dependent kinase 9*  / complex
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex
 ENSDARG00000088123 znf217 / zinc finger protein 217 / O75362*  / complex
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction
 ENSDARG00000100940 nr5a2 / nuclear receptor subfamily 5, group A, member 2 / O00482*  / complex






 

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