ENSDARG00000017007


Danio rerio

Features
Gene ID: ENSDARG00000017007
  
Biological name :nr4a2a
  
Synonyms : nr4a2a / nuclear receptor subfamily 4, group A, member 2a
  
Possible biological names infered from orthology : NR4A2 / nuclear receptor subfamily 4 group A member 2 / P43354 / Q06219
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 5040985
Gene end: 5046315
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000100256
Ensembl peptide - ENSDARP00000124937
Ensembl peptide - ENSDARP00000144147
NCBI entrez gene - 100008101     See in Manteia.
swissprot - F1RER4
ZFIN ID - ZDB-GENE-990415-184
Ensembl - ENSDARG00000017007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NR4A2ENSGALG00000012538Gallus gallus
 NR4A2ENSG00000153234Homo sapiens
 Nr4a2ENSMUSG00000026826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr4a2b / nuclear receptor subfamily 4, group A, member 2bENSDARG0000004453269
nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6*ENSDARG0000005585448
nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736*ENSDARG0000000079646
esrrb / esrrga / estrogen-related receptor betaENSDARG0000000486119
esrrb / estrogen-related receptor beta / O95718*ENSDARG0000010084718
esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 *ENSDARG0000006926617
esrrgb / estrogen-related receptor gamma bENSDARG0000001169617
esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000003418117
esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000001645416
esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *ENSDARG0000000411116
nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*ENSDARG0000002503216
ar / androgen receptor / P10275* / P19091*ENSDARG0000006797616
nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*ENSDARG0000010208214
pgr / progesterone receptor / P06401* / Q00175*ENSDARG0000003596613
esrrd / estrogen-related receptor deltaENSDARG0000001506410
FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSDARG000001110439


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor
 IPR003070  Orphan nuclear receptor
 IPR003073  Orphan nuclear receptor, NURR type
 IPR013088  Zinc finger, NHR/GATA-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021884 forebrain neuron development IMP
 biological_processGO:0021953 central nervous system neuron differentiation IGI
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Nuclear Receptor transcription pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain neuron apoptotic , abnormal
Show

 ZFA:0000109 forebrain forebrain adrenergic neuron decreased amount , abnormal
Show

 ZFA:0000152 retina retina lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000402 olfactory bulb olfactory bulb adrenergic neuron decreased amount , abnormal
Show

 ZFA:0000408 periventricular nucleus of caudal tuberculum periventricular nucleus of caudal tuberculum has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000418 pretectum pretectum adrenergic neuron decreased amount , abnormal
pretectum lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000458 ventral thalamus ventral thalamus has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000470 preoptic area preoptic area adrenergic neuron decreased amount , abnormal
preoptic area lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum adrenergic neuron decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism increased behavioural activity , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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