ENSDARG00000067976


Danio rerio

Features
Gene ID: ENSDARG00000067976
  
Biological name :ar
  
Synonyms : androgen receptor / ar
  
Possible biological names infered from orthology : P10275 / P19091
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 35561607
Gene end: 35679140
  
Corresponding Affymetrix probe sets: DrAffx.2.97.A1_at (Zebrafish Array)   DrAffx.2.97.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000088795
NCBI entrez gene - 100005148     See in Manteia.
swissprot - A4GT83
ZFIN ID - ZDB-GENE-060131-1
Ensembl - ENSDARG00000067976
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARENSGALG00000030879Gallus gallus
 ARENSG00000169083Homo sapiens
 ArENSMUSG00000046532Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*ENSDARG0000010208226
nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*ENSDARG0000002503226
pgr / progesterone receptor / P06401* / Q00175*ENSDARG0000003596622
esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *ENSDARG0000000411112
esr2b / estrogen receptor 2b / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000003418112
esr2a / estrogen receptor 2a / ESR2* / O08537* / Q92731* / estrogen receptor 2* / Estrogen receptor beta *ENSDARG0000001645412
esrrb / esrrga / estrogen-related receptor betaENSDARG0000000486112
nr4a3 / nuclear receptor subfamily 4, group A, member 3 / Q92570* / Q9QZB6*ENSDARG0000005585412
esrra / estrogen-related receptor alpha / O08580* / P11474* / Steroid hormone receptor ERR1 *ENSDARG0000006926612
nr4a2a / nuclear receptor subfamily 4, group A, member 2a / NR4A2* / Q06219* / P43354* / nuclear receptor subfamily 4 group A member 2*ENSDARG0000001700712
esrrgb / estrogen-related receptor gamma bENSDARG0000001169611
esrrb / estrogen-related receptor beta / O95718*ENSDARG0000010084711
nr4a2b / nuclear receptor subfamily 4, group A, member 2bENSDARG0000004453211
nr4a1 / nuclear receptor subfamily 4, group A, member 1 / P12813* / P22736*ENSDARG0000000079610
FO681288.3 / ESRRG* / P62508* / P62509* / estrogen related receptor gamma* / Mus musculus estrogen-related receptor gamma (Esrrg), transcript variant 5, mRNA.*ENSDARG000001110437
esrrd / estrogen-related receptor deltaENSDARG000000150646


Protein motifs (from Interpro)
Interpro ID Name
 IPR000536  Nuclear hormone receptor, ligand-binding domain
 IPR001628  Zinc finger, nuclear hormone receptor-type
 IPR001723  Nuclear hormone receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008049 male courtship behavior IMP
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003707 steroid hormone receptor activity IDA
 molecular_functionGO:0004882 androgen receptor activity IDA
 molecular_functionGO:0005497 androgen binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
RUNX2 regulates osteoblast differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex
 ENSDARG00000008447 fkbp4 / FK506 binding protein 4 / P30416* / Q02790* / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed*  / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / reaction / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / complex / reaction
 ENSDARG00000038543 wdr48b / Q6PFM9 / WD repeat domain 48b / WDR48* / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / complex / reaction
 ENSDARG00000017929 ncoa2 / nuclear receptor coactivator 2 / Q15596* / Q61026*  / complex / reaction
 ENSDARG00000105345 zgc:173552  / complex / reaction
 ENSDARG00000078109 A4FUN7 / usp12a / ubiquitin specific peptidase 12a / USP12* / Q9D9M2* / O75317* / ubiquitin specific peptidase 12*  / complex
 ENSDARG00000041239 wdr20b / WD repeat domain 20b / WDR20* / Q8TBZ3* / Q9D5R2* / Wdr20rt* / WD repeat domain 20* / WD repeat domain 20, retrogene*  / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction






 

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