ENSDARG00000008447


Danio rerio

Features
Gene ID: ENSDARG00000008447
  
Biological name :fkbp4
  
Synonyms : FK506 binding protein 4 / fkbp4
  
Possible biological names infered from orthology : P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 6536293
Gene end: 6550378
  
Corresponding Affymetrix probe sets: Dr.3473.1.S1_at (Zebrafish Array)   NM_201469_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124772
Ensembl peptide - ENSDARP00000013076
NCBI entrez gene - 321795     See in Manteia.
RefSeq - XM_005173616
RefSeq - NM_201469
RefSeq Peptide - NP_958877
swissprot - F8W2D1
swissprot - F1RCG7
ZFIN ID - ZDB-GENE-030131-514
Ensembl - ENSDARG00000008447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FKBP4ENSGALG00000014331Gallus gallus
 FKBP4ENSG00000004478Homo sapiens
 Fkbp4ENSMUSG00000030357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fkbp5 / FK506 binding protein 5 / Q13451* / Q64378* / Peptidyl-prolyl cis-trans isomerase FKBP5 *ENSDARG0000002839651
fkbp1aa / FK506 binding protein 1AaENSDARG0000002268413
fkbp1b / FK506 binding protein 1bENSDARG0000005262512
fkbp1ab / FK506 binding protein 1AbENSDARG0000003356712
fkbp3 / FK506 binding protein 3 / Q00688*ENSDARG000000980599


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR031212  Peptidyl-prolyl cis-trans isomerase FKBP4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA
 molecular_functionGO:0005528 FK506 binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord neuron apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism anatomical axis curved , abnormal
whole organism anterior-posterior axis decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / complex / reaction
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / complex / reaction
 ENSDARG00000037284 ptges3a / prostaglandin E synthase 3a (cytosolic) / PTGES3* / Q9R0Q7* / Q15185* / prostaglandin E synthase 3*  / complex / reaction
 ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*  / complex
 ENSDARG00000067976 ar / androgen receptor / P10275* / P19091*  / complex
 ENSDARG00000102082 nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*  / complex
 ENSDARG00000028396 fkbp5 / FK506 binding protein 5 / Q13451* / Q64378* / Peptidyl-prolyl cis-trans isomerase FKBP5 *  / reaction
 ENSDARG00000004906 stip1 / stress-induced phosphoprotein 1 / P31948* / Q60864*  / reaction / complex






 

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