ENSG00000004478


Homo sapiens

Features
Gene ID: ENSG00000004478
  
Biological name :FKBP4
  
Synonyms : FK506 binding protein 4 / FKBP4 / Q02790
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.33
Gene start: 2794953
Gene end: 2805423
  
Corresponding Affymetrix probe sets: 1560303_at (Human Genome U133 Plus 2.0 Array)   1560305_x_at (Human Genome U133 Plus 2.0 Array)   200894_s_at (Human Genome U133 Plus 2.0 Array)   200895_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486800
Ensembl peptide - ENSP00000442193
Ensembl peptide - ENSP00000446368
Ensembl peptide - ENSP00000001008
Ensembl peptide - ENSP00000438491
Ensembl peptide - ENSP00000439703
NCBI entrez gene - 2288     See in Manteia.
OMIM - 600611
RefSeq - XM_011520929
RefSeq - NM_002014
RefSeq Peptide - NP_002005
swissprot - H0YFG2
swissprot - H0YG86
swissprot - F5H120
swissprot - Q02790
swissprot - F5H1U3
Ensembl - ENSG00000004478
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp4ENSDARG00000008447Danio rerio
 FKBP4ENSGALG00000014331Gallus gallus
 Fkbp4ENSMUSG00000030357Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FKBP5 / Q13451 / FK506 binding protein 5ENSG0000009606054
FKBP3 / Q00688 / FK506 binding protein 3ENSG0000010044213
FKBP1A / P62942 / FK506 binding protein 1AENSG0000008883212
FKBP1B / P68106 / FK506 binding protein 1BENSG0000011978211
FKBP1C / FK506 binding protein 1CENSG0000019822511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013105  Tetratricopeptide repeat 2
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR031212  Peptidyl-prolyl cis-trans isomerase FKBP4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006463 steroid hormone receptor complex assembly IEA
 biological_processGO:0006825 copper ion transport IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0031111 negative regulation of microtubule polymerization or depolymerization ISS
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0031503 protein-containing complex localization IEA
 biological_processGO:0046661 male sex differentiation IEA
 biological_processGO:0048608 reproductive structure development IEA
 biological_processGO:0061077 chaperone-mediated protein folding IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005528 FK506 binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0030674 protein binding, bridging TAS
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0032767 copper-dependent protein binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169083 AR / P10275 / androgen receptor  / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000082175 PGR / P06401 / progesterone receptor  / complex
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / reaction / complex
 ENSG00000113580 NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1  / complex
 ENSG00000151623 NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2  / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex / reaction
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction / complex
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / reaction
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction






 

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