ENSG00000119782


Homo sapiens

Features
Gene ID: ENSG00000119782
  
Biological name :FKBP1B
  
Synonyms : FK506 binding protein 1B / FKBP1B / P68106
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.3
Gene start: 24049701
Gene end: 24063681
  
Corresponding Affymetrix probe sets: 206857_s_at (Human Genome U133 Plus 2.0 Array)   209931_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370379
Ensembl peptide - ENSP00000406593
Ensembl peptide - ENSP00000416349
Ensembl peptide - ENSP00000370373
Ensembl peptide - ENSP00000397444
NCBI entrez gene - 2281     See in Manteia.
OMIM - 600620
RefSeq - XM_017003596
RefSeq - NM_001322963
RefSeq - NM_001322964
RefSeq - NM_004116
RefSeq - NM_054033
RefSeq - XM_017003593
RefSeq - XM_017003594
RefSeq - XM_017003595
RefSeq Peptide - NP_001309892
RefSeq Peptide - NP_004107
RefSeq Peptide - NP_473374
RefSeq Peptide - NP_001309893
swissprot - F8W6G9
swissprot - G5E9U6
swissprot - H7C0Y3
swissprot - P68106
Ensembl - ENSG00000119782
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FKBP1BENSGALG00000016500Gallus gallus
 Fkbp1bENSMUSG00000020635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FKBP1A / P62942 / FK506 binding protein 1AENSG0000008883283
FKBP1C / FK506 binding protein 1CENSG0000019822580
FKBP4 / Q02790 / FK506 binding protein 4ENSG0000000447848
FKBP5 / Q13451 / FK506 binding protein 5ENSG0000009606048
FKBP3 / Q00688 / FK506 binding protein 3ENSG0000010044247


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0006458 "de novo" protein folding TAS
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IEA
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0019227 neuronal action potential propagation IEA
 biological_processGO:0022417 protein maturation by protein folding TAS
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source TAS
 biological_processGO:0042026 protein refolding TAS
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0048680 positive regulation of axon regeneration IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051284 positive regulation of sequestering of calcium ion IDA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051775 response to redox state IDA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IDA
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction TAS
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IC
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005219 ryanodine-sensitive calcium-release channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity IDA
 molecular_functionGO:0030551 cyclic nucleotide binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000119782 FKBP1B / P68106 / FK506 binding protein 1B  / complex






 

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