ENSMUSG00000020635


Mus musculus

Features
Gene ID: ENSMUSG00000020635
  
Biological name :Fkbp1b
  
Synonyms : Fkbp1b / Peptidyl-prolyl cis-trans isomerase FKBP1B / Q9Z2I2
  
Possible biological names infered from orthology : FK506 binding protein 1B / P68106
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 4833174
Gene end: 4841591
  
Corresponding Affymetrix probe sets: 10399308 (MoGene1.0st)   1449429_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020964
Ensembl peptide - ENSMUSP00000151687
NCBI entrez gene - 14226     See in Manteia.
MGI - MGI:1336205
RefSeq - XM_006514974
RefSeq - NM_016863
RefSeq Peptide - NP_058559
swissprot - Q80YE1
swissprot - Q9Z2I2
swissprot - A9E3L2
Ensembl - ENSMUSG00000020635
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FKBP1BENSGALG00000016500Gallus gallus
 FKBP1BENSG00000119782Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*ENSMUSG0000003296681
Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*ENSMUSG0000003035749
Fkbp3 / Q62446 / Peptidyl-prolyl cis-trans isomerase FKBP3 / Q00688* / FK506 binding protein 3*ENSMUSG0000002094947
Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*ENSMUSG0000002422246


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006939 smooth muscle contraction IMP
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010459 negative regulation of heart rate IMP
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
 biological_processGO:0019227 neuronal action potential propagation IMP
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0048680 positive regulation of axon regeneration IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051280 negative regulation of release of sequestered calcium ion into cytosol ISO
 biological_processGO:0051284 positive regulation of sequestering of calcium ion ISO
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0051775 response to redox state ISO
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity ISO
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IDA
 cellular_componentGO:0034704 calcium channel complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity ISO
 molecular_functionGO:0030551 cyclic nucleotide binding IEA
 molecular_functionGO:0044325 ion channel binding IPI


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0008543 atrial fibrillation "asynchronous contraction or quivering of individual cardiac muscle fibers in the atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm2Amks/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1(tTA)Tilg/Ednrbtm3(tetO)Tilg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020635 Fkbp1b / Q9Z2I2 / Peptidyl-prolyl cis-trans isomerase FKBP1B / P68106* / FK506 binding protein 1B*  / complex






 

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