ENSMUSG00000024222


Mus musculus

Features
Gene ID: ENSMUSG00000024222
  
Biological name :Fkbp5
  
Synonyms : Fkbp5 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q64378
  
Possible biological names infered from orthology : FK506 binding protein 5 / Q13451
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 28399095
Gene end: 28517524
  
Corresponding Affymetrix probe sets: 10449452 (MoGene1.0st)   1416125_at (Mouse Genome 430 2.0 Array)   1447736_at (Mouse Genome 430 2.0 Array)   1448231_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116466
Ensembl peptide - ENSMUSP00000136245
Ensembl peptide - ENSMUSP00000078382
Ensembl peptide - ENSMUSP00000110440
NCBI entrez gene - 14229     See in Manteia.
MGI - MGI:104670
RefSeq - NM_010220
RefSeq Peptide - NP_034350
swissprot - B8JJC2
swissprot - Q4FJN2
swissprot - Q64378
Ensembl - ENSMUSG00000024222
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp5ENSDARG00000028396Danio rerio
 FKBP5ENSGALG00000042148Gallus gallus
 FKBP5ENSG00000096060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*ENSMUSG0000003035754
Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*ENSMUSG0000003296611
Fkbp1b / Q9Z2I2 / Peptidyl-prolyl cis-trans isomerase FKBP1B / P68106* / FK506 binding protein 1B*ENSMUSG0000002063511
Fkbp3 / Q62446 / Peptidyl-prolyl cis-trans isomerase FKBP3 / Q00688* / FK506 binding protein 3*ENSMUSG0000002094911


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR031210  Peptidyl-prolyl cis-trans isomerase FKBP5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0061077 chaperone-mediated protein folding ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding IBA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031072 heat shock protein binding ISO


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
ESR-mediated signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003124 hypospadia "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou,Fkbp5Gt(RRC236)Byg/Fkbp5+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

Allelic Composition: Fkbp5tm1b(KOMP)Wtsi/Fkbp5+
Genetic Background: C57BL/6N-Fkbp5tm1b(KOMP)Wtsi/Ucd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / reaction / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / reaction / complex
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / reaction / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction






 

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