ENSMUSG00000024966


Mus musculus

Features
Gene ID: ENSMUSG00000024966
  
Biological name :Stip1
  
Synonyms : Q60864 / Stip1 / Stress-induced-phosphoprotein 1
  
Possible biological names infered from orthology : P31948
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7020696
Gene end: 7040026
  
Corresponding Affymetrix probe sets: 10465604 (MoGene1.0st)   1415909_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025918
NCBI entrez gene - 20867     See in Manteia.
MGI - MGI:109130
RefSeq - NM_016737
RefSeq Peptide - NP_058017
swissprot - Q60864
Ensembl - ENSMUSG00000024966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stip1ENSDARG00000004906Danio rerio
 STIP1ENSG00000168439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001440  Tetratricopeptide repeat 1
 IPR006636  Heat shock chaperonin-binding
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023392  Mitochondrial outer membrane translocase complex, Tom20 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0010038 abnormal placenta physiology "any functional anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

Allelic Composition: Stip1tm1.2Mamp/Stip1+
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Usp14ax-J/Usp14ax-J
Genetic Background: B6.Cg-Usp14ax-J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / reaction / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / reaction
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / complex / reaction
 ENSMUSG00000028410 Dnaja1 / P63037 / DnaJ homolog subfamily A member 1 / P31689* / DnaJ heat shock protein family (Hsp40) member A1*  / reaction
 ENSMUSG00000031701 Dnaja2 / Q9QYJ0 / DnaJ homolog subfamily A member 2 / O60884* / DnaJ heat shock protein family (Hsp40) member A2*  / reaction
 ENSMUSG00000030077 Chl1 / P70232 / Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein / O00533* / cell adhesion molecule L1 like*  / reaction / complex
 ENSMUSG00000032285 Dnaja4 / Q9JMC3 / Mus musculus DnaJ heat shock protein family (Hsp40) member A4 (Dnaja4), transcript variant 1, mRNA. / Q8WW22* / DnaJ heat shock protein family (Hsp40) member A4*  / reaction
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / reaction / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex






 

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