ENSMUSG00000090877


Mus musculus

Features
Gene ID: ENSMUSG00000090877
  
Biological name :Hspa1b
  
Synonyms : Heat shock 70 kDa protein 1B / Hspa1b / P17879
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 1A / heat shock protein family A (Hsp70) member 1B / HSPA1A / P0DMV8 / P0DMV9
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34956436
Gene end: 34959238
  
Corresponding Affymetrix probe sets: 10450367 (MoGene1.0st)   1427126_at (Mouse Genome 430 2.0 Array)   1427127_x_at (Mouse Genome 430 2.0 Array)   1452318_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133815
NCBI entrez gene - 15511     See in Manteia.
MGI - MGI:99517
RefSeq - NM_010478
RefSeq Peptide - NP_034608
swissprot - P17879
Ensembl - ENSMUSG00000090877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSPA1AENSG00000204389Homo sapiens
 HSPA1BENSG00000204388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG00000091971100
Hspa1l / P16627 / Heat shock 70 kDa protein 1-like / P34931* / heat shock protein family A (Hsp70) member 1 like*ENSMUSG0000000703388
Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*ENSMUSG0000001565685
Hspa2 / P17156 / Heat shock-related 70 kDa protein 2 / P54652* / heat shock protein family A (Hsp70) member 2*ENSMUSG0000005997083
Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*ENSMUSG0000002686461
Hspa14 / Q99M31 / Heat shock 70 kDa protein 14 / Q0VDF9* / heat shock protein family A (Hsp70) member 14*ENSMUSG0000010986526


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007339 binding of sperm to zona pellucida IDA
 biological_processGO:0009408 response to heat IDA
 biological_processGO:0042026 protein refolding ISS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0090063 positive regulation of microtubule nucleation ISS
 biological_processGO:1901673 regulation of mitotic spindle assembly ISS
 cellular_componentGO:0002199 zona pellucida receptor complex IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hspa1atm1Msk/Hspa1a+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hspa1btm1Msk/Hspa1b+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Hspa1btm1.1Msk/Hspa1btm1.1Msk
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/Mp-Faslpr atms

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspa1atm1Msk/Hspa1a+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

Allelic Composition: Hspa1btm1Clib/Hspa1btm1Clib
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Birc6tm1Nai/Birc6tm1Nai
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005483 Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*  / complex / reaction
 ENSMUSG00000014195 Dnajc7 / Q9QYI3 / DnaJ homolog subfamily C member 7 / Q99615* / DnaJ heat shock protein family (Hsp40) member C7*  / reaction
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / complex / reaction
 ENSMUSG00000028410 Dnaja1 / P63037 / DnaJ homolog subfamily A member 1 / P31689* / DnaJ heat shock protein family (Hsp40) member A1*  / complex / reaction
 ENSMUSG00000031701 Dnaja2 / Q9QYJ0 / DnaJ homolog subfamily A member 2 / O60884* / DnaJ heat shock protein family (Hsp40) member A2*  / reaction / complex
 ENSMUSG00000029014 Dnajc2 / P54103 / DnaJ homolog subfamily C member 2 / Q99543* / DnaJ heat shock protein family (Hsp40) member C2*  / reaction
 ENSMUSG00000032285 Dnaja4 / Q9JMC3 / Mus musculus DnaJ heat shock protein family (Hsp40) member A4 (Dnaja4), transcript variant 1, mRNA. / Q8WW22* / DnaJ heat shock protein family (Hsp40) member A4*  / reaction / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000062797 Q9DD02 / Hikeshi / Protein Hikeshi / Q53FT3* / Hikeshi, heat shock protein nuclear import factor*  / reaction / complex
 ENSMUSG00000029657 Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*  / reaction
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / complex / reaction
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / reaction / complex






 

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