Manteia

ENSMUSG00000029657

Mus musculus

Features

Gene ID:	ENSMUSG00000029657

Biological name :	Hsph1

Synonyms :	Hsph1 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q61699

Possible biological names infered from orthology :	heat shock protein family H (Hsp110) member 1 / Q92598

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	G3
Gene start:	149614287
Gene end:	149636376

Corresponding Affymetrix probe sets:	10535904 (MoGene1.0st) 1423566_a_at (Mouse Genome 430 2.0 Array) 1425993_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000143925 Ensembl peptide - ENSMUSP00000144654 Ensembl peptide - ENSMUSP00000144413 Ensembl peptide - ENSMUSP00000144297 Ensembl peptide - ENSMUSP00000144043 Ensembl peptide - ENSMUSP00000074392 Ensembl peptide - ENSMUSP00000143913 NCBI entrez gene - 15505 See in Manteia. MGI - MGI:105053 RefSeq - XM_006504916 RefSeq - NM_001347534 RefSeq - NM_013559 RefSeq - XM_006504914 RefSeq - XM_006504915 RefSeq Peptide - NP_001334463 RefSeq Peptide - NP_038587 swissprot - A0A0J9YTZ7 swissprot - D3Z3I9 swissprot - Q61699 swissprot - D3Z027 swissprot - E9Q0U7 Ensembl - ENSMUSG00000029657

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hsph1	ENSDARG00000019874	Danio rerio
HSPH1	ENSGALG00000017077	Gallus gallus
HSPH1	ENSG00000120694	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hspa4 / heat shock protein 4 / P34932* / heat shock protein family A (Hsp70) member 4*	ENSMUSG00000020361	61
Hspa4l / P48722 / Heat shock 70 kDa protein 4L / O95757* / heat shock protein family A (Hsp70) member 4 like*	ENSMUSG00000025757	56
Hyou1 / Q9JKR6 / Hypoxia up-regulated protein 1 / Q9Y4L1* / hypoxia up-regulated 1*	ENSMUSG00000032115	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR013126	Heat shock protein 70 family
IPR018181	Heat shock protein 70, conserved site
IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
IPR029048	Heat shock protein 70kD, C-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006986	response to unfolded protein	TAS
biological_process	GO:0043524	negative regulation of neuron apoptotic process	TAS
biological_process	GO:0045345	positive regulation of MHC class I biosynthetic process	TAS
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
biological_process	GO:0051085	chaperone cofactor-dependent protein refolding	IDA
biological_process	GO:0051135	positive regulation of NK T cell activation	TAS
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	IDA
biological_process	GO:0070507	regulation of microtubule cytoskeleton organization	NAS
biological_process	GO:1903748	negative regulation of establishment of protein localization to mitochondrion	IMP
biological_process	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IMP
biological_process	GO:1903753	negative regulation of p38MAPK cascade	IGI
biological_process	GO:2001234	negative regulation of apoptotic signaling pathway	IMP
cellular_component	GO:0005576	extracellular region	TAS
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005874	microtubule	IDA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0000774	adenyl-nucleotide exchange factor activity	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0043014	alpha-tubulin binding	IDA

Pathways (from Reactome)

Pathway description

Regulation of HSF1-mediated heat shock response

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Efemp2^tm1.1Chu/Efemp2⁺ Genetic Background: B6(SJL)-Efemp2^tm1.1Chu
MP:0006058	decreased cerebral infarction size	"decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Efemp2^tm1.1Chu/Efemp2⁺ Genetic Background: B6(SJL)-Efemp2^tm1.1Chu
MP:0006059	decreased susceptibility to ischemic brain injury	"decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Efemp2^tm1.1Chu/Efemp2⁺ Genetic Background: B6(SJL)-Efemp2^tm1.1Chu

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000090877	P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*	/ reaction
ENSMUSG00000038188	Q5ND28 / Scarf1 / Scavenger receptor class F member 1 / Q14162*	/ reaction / complex
ENSMUSG00000091971	Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr