ENSMUSG00000032115


Mus musculus

Features
Gene ID: ENSMUSG00000032115
  
Biological name :Hyou1
  
Synonyms : Hyou1 / Hypoxia up-regulated protein 1 / Q9JKR6
  
Possible biological names infered from orthology : hypoxia up-regulated 1 / Q9Y4L1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.2
Gene start: 44379490
Gene end: 44392369
  
Corresponding Affymetrix probe sets: 10584712 (MoGene1.0st)   1423290_at (Mouse Genome 430 2.0 Array)   1423291_s_at (Mouse Genome 430 2.0 Array)   1451913_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125594
Ensembl peptide - ENSMUSP00000124177
Ensembl peptide - ENSMUSP00000148882
Ensembl peptide - ENSMUSP00000068594
Ensembl peptide - ENSMUSP00000123700
Ensembl peptide - ENSMUSP00000123749
NCBI entrez gene - 12282     See in Manteia.
MGI - MGI:108030
RefSeq - XM_006509962
RefSeq - NM_021395
RefSeq - XM_006509959
RefSeq - XM_006509960
RefSeq - XM_006509961
RefSeq Peptide - NP_067370
swissprot - Q9JKR6
swissprot - F6TRP3
swissprot - E0CYZ2
swissprot - A0A1L1SQ34
Ensembl - ENSMUSG00000032115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hyou1ENSDARG00000013670Danio rerio
 HYOU1ENSGALG00000007659Gallus gallus
 HYOU1ENSG00000149428Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*ENSMUSG0000002965724
Hspa4l / P48722 / Heat shock 70 kDa protein 4L / O95757* / heat shock protein family A (Hsp70) member 4 like*ENSMUSG0000002575724
Hspa4 / heat shock protein 4 / P34932* / heat shock protein family A (Hsp70) member 4*ENSMUSG0000002036124


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0071456 cellular response to hypoxia ISO
 biological_processGO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1903382 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Hyou1tm1Oga/Hyou1+,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6J

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0013219 abnormal substantia nigra pars compacta morphology "any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species" [MGI:anna]
Show

Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038188 Q5ND28 / Scarf1 / Scavenger receptor class F member 1 / Q14162*  / reaction / complex






 

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