ENSMUSG00000025757


Mus musculus

Features
Gene ID: ENSMUSG00000025757
  
Biological name :Hspa4l
  
Synonyms : Heat shock 70 kDa protein 4L / Hspa4l / P48722
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 4 like / O95757
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 40744495
Gene end: 40796103
  
Corresponding Affymetrix probe sets: 10491780 (MoGene1.0st)   1418253_a_at (Mouse Genome 430 2.0 Array)   1429106_at (Mouse Genome 430 2.0 Array)   1439093_at (Mouse Genome 430 2.0 Array)   1449010_at (Mouse Genome 430 2.0 Array)   1458385_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144787
Ensembl peptide - ENSMUSP00000145468
Ensembl peptide - ENSMUSP00000145405
Ensembl peptide - ENSMUSP00000145243
Ensembl peptide - ENSMUSP00000103721
NCBI entrez gene - 18415     See in Manteia.
MGI - MGI:107422
RefSeq - XM_006500767
RefSeq - NM_011020
RefSeq - XM_006500766
RefSeq Peptide - NP_035150
swissprot - E0CY23
swissprot - P48722
swissprot - A0A0N4SVU2
swissprot - A0A0N4SW76
Ensembl - ENSMUSG00000025757
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa4lENSDARG00000053544Danio rerio
 HSPA4LENSGALG00000010185Gallus gallus
 HSPA4LENSG00000164070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspa4 / heat shock protein 4 / P34932* / heat shock protein family A (Hsp70) member 4*ENSMUSG0000002036163
Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*ENSMUSG0000002965758
Hyou1 / Q9JKR6 / Hypoxia up-regulated protein 1 / Q9Y4L1* / hypoxia up-regulated 1*ENSMUSG0000003211528


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding ISS
 biological_processGO:0006986 response to unfolded protein ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

Allelic Composition: Hspa4ltm1Imad/Hspa4ltm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-h/Tyrc-25H
Genetic Background: STOCK Tyrc-h/Tyrc-25H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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