ENSMUSG00000020361


Mus musculus

Features
Gene ID: ENSMUSG00000020361
  
Biological name :Hspa4
  
Synonyms : heat shock protein 4 / Hspa4
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 4 / P34932
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53259814
Gene end: 53300457
  
Corresponding Affymetrix probe sets: 10385790 (MoGene1.0st)   1416146_at (Mouse Genome 430 2.0 Array)   1416147_at (Mouse Genome 430 2.0 Array)   1435194_at (Mouse Genome 430 2.0 Array)   1440575_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020630
NCBI entrez gene - 15525     See in Manteia.
MGI - MGI:1342292
RefSeq - NM_008300
RefSeq Peptide - NP_032326
swissprot - Q3U2G2
Ensembl - ENSMUSG00000020361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa4aENSDARG00000004754Danio rerio
 hspa4bENSDARG00000018989Danio rerio
 HSPA4ENSGALG00000040882Gallus gallus
 HSPA4ENSG00000170606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*ENSMUSG0000002965763
Hspa4l / P48722 / Heat shock 70 kDa protein 4L / O95757* / heat shock protein family A (Hsp70) member 4 like*ENSMUSG0000002575763
Hyou1 / Q9JKR6 / Hypoxia up-regulated protein 1 / Q9Y4L1* / hypoxia up-regulated 1*ENSMUSG0000003211528


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045040 protein import into mitochondrial outer membrane IEA
 biological_processGO:0051131 chaperone-mediated protein complex assembly IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0003214 neurofibrillary tangles "dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

Allelic Composition: Hspa4tm1.1Miv/Hspa4tm1.1Miv,Tg(APPSWE)2576Kha/0
Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm17.1Sia/Gt(ROSA)26Sortm17.1Sia
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nedd4landi/Nedd4landi
Genetic Background: BALB/cByJ-Nedd4landi/EiJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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