ENSMUSG00000038188


Mus musculus

Features
Gene ID: ENSMUSG00000038188
  
Biological name :Scarf1
  
Synonyms : Q5ND28 / Scarf1 / Scavenger receptor class F member 1
  
Possible biological names infered from orthology : Q14162
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75513540
Gene end: 75526582
  
Corresponding Affymetrix probe sets: 10378637 (MoGene1.0st)   1434490_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044248
Ensembl peptide - ENSMUSP00000120097
Ensembl peptide - ENSMUSP00000114090
NCBI entrez gene - 380713     See in Manteia.
MGI - MGI:2449455
RefSeq - NM_001004157
RefSeq Peptide - NP_001004157
swissprot - D6RJK6
swissprot - B7ZC28
swissprot - Q5ND28
Ensembl - ENSMUSG00000038188
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scarf1ENSDARG00000077285Danio rerio
 Q14162ENSG00000074660Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59222 / Scarf2 / Scavenger receptor class F member 2 / Q96GP6*ENSMUSG0000001201734
Megf11 / Q80T91 / Multiple epidermal growth factor-like domains protein 11 / A6BM72* / multiple EGF like domains 11*ENSMUSG0000003646625
Pear1 / Q8VIK5 / platelet endothelial aggregation receptor 1 / Q5VY43*ENSMUSG0000002807325
Megf10 / Q6DIB5 / Multiple epidermal growth factor-like domains protein 10 / Q96KG7* / multiple EGF like domains 10*ENSMUSG0000002459325
Megf6 / multiple EGF like domains 6 / O75095*ENSMUSG0000005775125
Egfem1 / Q8C088 / EGF-like and EMI domain-containing protein 1 ENSMUSG000000636006


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR033329  Scavenger receptor class F member 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0016322 neuron remodeling IMP
 biological_processGO:0016358 dendrite development IDA
 biological_processGO:0048680 positive regulation of axon regeneration IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001280 loss of vibrissae "inability to retain the whiskers" [J:45400]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm2Tuzi/Prnptm2Edin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011420 pyuria "presence of pus in the urine when voided; a sign of inflammation often related to urinary tract infection" [MGI:anna]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / complex / reaction
 ENSMUSG00000032115 Hyou1 / Q9JKR6 / Hypoxia up-regulated protein 1 / Q9Y4L1* / hypoxia up-regulated 1*  / reaction / complex
 ENSMUSG00000029657 Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*  / reaction / complex






 

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