ENSMUSG00000028073


Mus musculus

Features
Gene ID: ENSMUSG00000028073
  
Biological name :Pear1
  
Synonyms : Pear1 / platelet endothelial aggregation receptor 1 / Q8VIK5
  
Possible biological names infered from orthology : Q5VY43
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 87747890
Gene end: 87824306
  
Corresponding Affymetrix probe sets: 10499216 (MoGene1.0st)   1425267_a_at (Mouse Genome 430 2.0 Array)   1425268_a_at (Mouse Genome 430 2.0 Array)   1430853_a_at (Mouse Genome 430 2.0 Array)   1445223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134451
Ensembl peptide - ENSMUSP00000029714
Ensembl peptide - ENSMUSP00000078090
Ensembl peptide - ENSMUSP00000088503
Ensembl peptide - ENSMUSP00000133323
Ensembl peptide - ENSMUSP00000133474
Ensembl peptide - ENSMUSP00000133480
Ensembl peptide - ENSMUSP00000133565
Ensembl peptide - ENSMUSP00000133626
Ensembl peptide - ENSMUSP00000133749
Ensembl peptide - ENSMUSP00000133988
Ensembl peptide - ENSMUSP00000134100
Ensembl peptide - ENSMUSP00000134215
Ensembl peptide - ENSMUSP00000134387
NCBI entrez gene - 73182     See in Manteia.
MGI - MGI:1920432
RefSeq - XM_006502146
RefSeq - NM_001032413
RefSeq - NM_001032414
RefSeq - NM_001289600
RefSeq - NM_001289601
RefSeq - NM_028460
RefSeq - NM_152799
RefSeq Peptide - NP_082736
RefSeq Peptide - NP_690012
RefSeq Peptide - NP_001276529
RefSeq Peptide - NP_001276530
RefSeq Peptide - NP_001027585
RefSeq Peptide - NP_001027586
swissprot - G3UYI7
swissprot - G3UYT5
swissprot - G3UX62
swissprot - G3UZD5
swissprot - Q8VIK5
swissprot - G3UWZ1
swissprot - G3UXB8
swissprot - G3UXM4
swissprot - G3UY90
Ensembl - ENSMUSG00000028073
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pear1ENSDARG00000060753Danio rerio
 PEAR1ENSGALG00000028622Gallus gallus
 PEAR1ENSG00000187800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Megf10 / Q6DIB5 / Multiple epidermal growth factor-like domains protein 10 / Q96KG7* / multiple EGF like domains 10*ENSMUSG0000002459346
Megf11 / Q80T91 / Multiple epidermal growth factor-like domains protein 11 / A6BM72* / multiple EGF like domains 11*ENSMUSG0000003646644
Megf6 / multiple EGF like domains 6 / O75095*ENSMUSG0000005775130
Q5ND28 / Scarf1 / Scavenger receptor class F member 1 / Q14162*ENSMUSG0000003818819
P59222 / Scarf2 / Scavenger receptor class F member 2 / Q96GP6*ENSMUSG0000001201718
Egfem1 / Q8C088 / EGF-like and EMI domain-containing protein 1 ENSMUSG000000636008


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011489  EMI domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043654 recognition of apoptotic cell IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IBA
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Col5a2tm1.2Dgr/Col5a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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