Manteia - Molecule gene

ENSMUSG00000091971

Mus musculus

Features

Gene ID:	ENSMUSG00000091971

Biological name :	Hspa1a

Synonyms :	Heat shock 70 kDa protein 1A / Hspa1a / Q61696

Possible biological names infered from orthology :	heat shock protein family A (Hsp70) member 1A / heat shock protein family A (Hsp70) member 1B / HSPA1B / P0DMV8 / P0DMV9

Species:	Mus musculus

Chr. number:	17
Strand:	-1
Band:	B1
Gene start:	34969190
Gene end:	34972156

Corresponding Affymetrix probe sets:	10450367 (MoGene1.0st) 10450369 (MoGene1.0st) 1452388_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000084586 NCBI entrez gene - 193740 See in Manteia. MGI - MGI:96244 RefSeq - NM_010479 RefSeq Peptide - NP_034609 swissprot - Q3TU85 swissprot - Q61696 Ensembl - ENSMUSG00000091971

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HSPA1A	ENSG00000204389	Homo sapiens
HSPA1B	ENSG00000204388	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*	ENSMUSG00000090877	100
Hspa1l / P16627 / Heat shock 70 kDa protein 1-like / P34931* / heat shock protein family A (Hsp70) member 1 like*	ENSMUSG00000007033	88
Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*	ENSMUSG00000015656	85
Hspa2 / P17156 / Heat shock-related 70 kDa protein 2 / P54652* / heat shock protein family A (Hsp70) member 2*	ENSMUSG00000059970	83
Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*	ENSMUSG00000026864	61
Hspa14 / Q99M31 / Heat shock 70 kDa protein 14 / Q0VDF9* / heat shock protein family A (Hsp70) member 14*	ENSMUSG00000109865	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR013126	Heat shock protein 70 family
IPR018181	Heat shock protein 70, conserved site
IPR029047	Heat shock protein 70kD, peptide-binding domain superfamily
IPR029048	Heat shock protein 70kD, C-terminal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000723	telomere maintenance	IMP
biological_process	GO:0006281	DNA repair	IMP
biological_process	GO:0006402	mRNA catabolic process	ISS
biological_process	GO:0006986	response to unfolded protein	ISS
biological_process	GO:0008285	negative regulation of cell proliferation	ISS
biological_process	GO:0009408	response to heat	IMP
biological_process	GO:0030308	negative regulation of cell growth	ISS
biological_process	GO:0042026	protein refolding	ISS
biological_process	GO:0090063	positive regulation of microtubule nucleation	ISS
biological_process	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	ISS
biological_process	GO:1901673	regulation of mitotic spindle assembly	ISS
cellular_component	GO:0000151	ubiquitin ligase complex	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005739	mitochondrion	ISS
cellular_component	GO:0005813	centrosome	ISS
cellular_component	GO:0005814	centriole	ISO
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0016234	inclusion body	ISO
cellular_component	GO:0016235	aggresome	ISO
cellular_component	GO:0016607	nuclear speck	ISO
cellular_component	GO:0048471	perinuclear region of cytoplasm	ISS
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	ISO
molecular_function	GO:0005102	signaling receptor binding	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	ISO
molecular_function	GO:0016887	ATPase activity	ISO
molecular_function	GO:0019899	enzyme binding	ISO
molecular_function	GO:0031072	heat shock protein binding	ISO
molecular_function	GO:0031249	denatured protein binding	ISO
molecular_function	GO:0031625	ubiquitin protein ligase binding	ISO
molecular_function	GO:0042623	ATPase activity, coupled	ISO
molecular_function	GO:0042826	histone deacetylase binding	ISO
molecular_function	GO:0044183	protein binding involved in protein folding	ISO
molecular_function	GO:0045296	cadherin binding	ISO
molecular_function	GO:0047485	protein N-terminus binding	ISO
molecular_function	GO:0051082	unfolded protein binding	ISO
molecular_function	GO:0055131	C3HC4-type RING finger domain binding	ISO
molecular_function	GO:0097718	disordered domain specific binding	ISO

Pathways (from Reactome)

Pathway description

Regulation of HSF1-mediated heat shock response

HSP90 chaperone cycle for steroid hormone receptors (SHR)

Attenuation phase

HSF1-dependent transactivation

AUF1 (hnRNP D0) binds and destabilizes mRNA

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Atcay^ji/Atcay^ji Genetic Background: JIGR Allelic Composition: Hspa1a^tm1Msk/Hspa1a⁺ Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: Hspa1a^tm1.1Msk/Hspa1a^tm1.1Msk Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0008943	increased sensitivity to induced cell death	"decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atcay^ji/Atcay^ji Genetic Background: JIGR

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000005483	Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*	/ reaction / complex
ENSMUSG00000014195	Dnajc7 / Q9QYI3 / DnaJ homolog subfamily C member 7 / Q99615* / DnaJ heat shock protein family (Hsp40) member C7*	/ reaction
ENSMUSG00000020063	Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*	/ complex / reaction
ENSMUSG00000023944	P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*	/ reaction / complex
ENSMUSG00000021270	P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*	/ reaction / complex
ENSMUSG00000030357	Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*	/ reaction / complex
ENSMUSG00000028410	Dnaja1 / P63037 / DnaJ homolog subfamily A member 1 / P31689* / DnaJ heat shock protein family (Hsp40) member A1*	/ complex / reaction
ENSMUSG00000031701	Dnaja2 / Q9QYJ0 / DnaJ homolog subfamily A member 2 / O60884* / DnaJ heat shock protein family (Hsp40) member A2*	/ reaction / complex
ENSMUSG00000029014	Dnajc2 / P54103 / DnaJ homolog subfamily C member 2 / Q99543* / DnaJ heat shock protein family (Hsp40) member C2*	/ reaction
ENSMUSG00000032285	Dnaja4 / Q9JMC3 / Mus musculus DnaJ heat shock protein family (Hsp40) member A4 (Dnaja4), transcript variant 1, mRNA. / Q8WW22* / DnaJ heat shock protein family (Hsp40) member A4*	/ reaction / complex
ENSMUSG00000071072	Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*	/ reaction
ENSMUSG00000055024	Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*	/ reaction
ENSMUSG00000062797	Q9DD02 / Hikeshi / Protein Hikeshi / Q53FT3* / Hikeshi, heat shock protein nuclear import factor*	/ complex / reaction
ENSMUSG00000024966	Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*	/ reaction / complex
ENSMUSG00000029657	Hsph1 / Q61699 / Mus musculus heat shock 105kDa/110kDa protein 1 (Hsph1), transcript variant 2, mRNA. / Q92598* / heat shock protein family H (Hsp110) member 1*	/ reaction
ENSMUSG00000024222	Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*	/ complex / reaction
ENSMUSG00000022556	Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*	/ reaction / complex

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr