ENSMUSG00000020063


Mus musculus

Features
Gene ID: ENSMUSG00000020063
  
Biological name :Sirt1
  
Synonyms : NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q923E4 / Sirt1
  
Possible biological names infered from orthology : Q96EB6 / sirtuin 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 63319005
Gene end: 63381704
  
Corresponding Affymetrix probe sets: 10369738 (MoGene1.0st)   1418640_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020257
Ensembl peptide - ENSMUSP00000101082
Ensembl peptide - ENSMUSP00000112595
Ensembl peptide - ENSMUSP00000117819
Ensembl peptide - ENSMUSP00000137565
NCBI entrez gene - 93759     See in Manteia.
MGI - MGI:2135607
RefSeq - NM_001159589
RefSeq - NM_019812
RefSeq Peptide - NP_062786
RefSeq Peptide - NP_001153061
swissprot - Q923E4
swissprot - Q3UNI1
swissprot - Q53Z05
swissprot - F6YAQ3
Ensembl - ENSMUSG00000020063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt1ENSDARG00000068064Danio rerio
 SIRT1ENSGALG00000002761Gallus gallus
 SIRT1ENSG00000096717Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt4 / Q8R216 / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial / Q9Y6E7* / sirtuin 4*ENSMUSG0000002952411
Sirt5 / Q8K2C6 / NAD-dependent protein deacylase sirtuin-5, mitochondrial / Q9NXA8* / sirtuin 5*ENSMUSG0000005402110


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair ISO
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000183 chromatin silencing at rDNA ISO
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair IMP
 biological_processGO:0000731 DNA synthesis involved in DNA repair IMP
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002821 positive regulation of adaptive immune response ISO
 biological_processGO:0006325 chromatin organization ISO
 biological_processGO:0006343 establishment of chromatin silencing ISO
 biological_processGO:0006344 maintenance of chromatin silencing ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006476 protein deacetylation IDA
 biological_processGO:0006642 triglyceride mobilization IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007346 regulation of mitotic cell cycle ISS
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010875 positive regulation of cholesterol efflux IMP
 biological_processGO:0010883 regulation of lipid storage IMP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0010934 macrophage cytokine production IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016239 positive regulation of macroautophagy IDA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0016575 histone deacetylation ISS
 biological_processGO:0018394 peptidyl-lysine acetylation ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0031393 negative regulation of prostaglandin biosynthetic process IMP
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0031937 positive regulation of chromatin silencing ISO
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0033158 regulation of protein import into nucleus, translocation ISO
 biological_processGO:0033210 leptin-mediated signaling pathway IMP
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IDA
 biological_processGO:0034983 peptidyl-lysine deacetylation ISO
 biological_processGO:0035356 cellular triglyceride homeostasis IMP
 biological_processGO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway IMP
 biological_processGO:0042127 regulation of cell proliferation ISO
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042542 response to hydrogen peroxide ISS
 biological_processGO:0042595 behavioral response to starvation IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0044321 response to leptin IMP
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process ISO
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045739 positive regulation of DNA repair ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050872 white fat cell differentiation IMP
 biological_processGO:0051097 negative regulation of helicase activity ISO
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IMP
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation ISO
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0055089 fatty acid homeostasis IMP
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway ISO
 biological_processGO:0061647 histone H3-K9 modification IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide ISO
 biological_processGO:0070857 regulation of bile acid biosynthetic process IMP
 biological_processGO:0070914 UV-damage excision repair ISO
 biological_processGO:0070932 histone H3 deacetylation ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0071441 negative regulation of histone H3-K14 acetylation ISO
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity ISO
 biological_processGO:0090335 regulation of brown fat cell differentiation IMP
 biological_processGO:0090400 stress-induced premature senescence ISO
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IDA
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1901984 negative regulation of protein acetylation ISO
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1904179 positive regulation of adipose tissue development IMP
 biological_processGO:1990619 histone H3-K9 deacetylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000111 positive regulation of macrophage apoptotic process IMP
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISS
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IDA
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation ISO
 biological_processGO:2000655 negative regulation of cellular response to testosterone stimulus ISO
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation ISS
 biological_processGO:2000773 negative regulation of cellular senescence ISS
 biological_processGO:2000774 positive regulation of cellular senescence ISS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope ISO
 cellular_componentGO:0005637 nuclear inner membrane ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex ISO
 cellular_componentGO:0005719 nuclear euchromatin ISS
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0033553 rDNA heterochromatin ISO
 cellular_componentGO:0035098 ESC/E(Z) complex ISS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity ISO
 molecular_functionGO:0019213 deacetylase activity ISO
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity EXP
 molecular_functionGO:0035257 nuclear hormone receptor binding ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043398 HLH domain binding ISO
 molecular_functionGO:0043425 bHLH transcription factor binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding ISO
 molecular_functionGO:0070403 NAD+ binding IEA
 molecular_functionGO:1990254 keratin filament binding ISO


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sim1Rgsc646/Sim1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sim1Rgsc646/Sim1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1.1Cxd/Sirt1+
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr2tm1Ytak/S1pr2tm1Ytak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
Genetic Background: FVB.129S6-Sirt1tm2.1Fwa

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Actbtm3.1(Sirt1)Npa/Actb+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ncor1tm1.1Ics/Ncor1tm1.1Ics,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Ncor1tm1.1Ics/Ncor1tm1.1Ics,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Sim1Rgsc646/Sim1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

Allelic Composition: Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Sirt1tm1.1Vlcg/Sirt1tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002627 teratoma "neoplasms composed of multiple tissue types; includes types not found in tissue in which lesion arises" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ncor1tm1.1Ics/Ncor1tm1.1Ics,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0003450 enlarged pancreas "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004902 abnormal uterus size "anomaly in the size of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005124 increased circulating prolactin level "greater than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005646 abnormal pituitary gland physiology "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0006197 ocular hypotelorism "the distance between the eyes is reduced" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0006241 abnormal placement of pupils "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008512 disorganized retinal inner nuclear layer "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008938 decreased pituitary gland weight "reduction in the average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm3Fwa/Sirt1tm3Fwa,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncor1tm1.1Ics/Ncor1tm1.1Ics,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

 MP:0009652 abnormal palatal rugae "any structural anomaly in the transversal ridges that develop on the secondary (hard) palate" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic Background: involves: 129/Sv * 129S6/SvEvTac

 MP:0010946 hyperpnea "breathing that is deeper and more rapid than normal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atp2b4tm1Ksch/Atp2b4tm1Ksch
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fgf18tm1Dor/Fgf18tm1Dor
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129

Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0011543 increased urine antidiuretic hormone level "an increased amount of antidiuretic hormone in the urine compared to the normal state" [MGI:anna]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Sirt1tm2.1Mcby/Sirt1tm2.1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0012298 hypoactivity in response to feed restriction "decreased activity after restriction of food" [MGI:csmith]
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Allelic Composition: Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
Genetic Background: FVB.129S6-Sirt1tm2.1Fwa

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1+,Trp53tm1Brd/Trp53+
Genetic Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

 MP:0013168 absent hindlimb buds "absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)

 MP:0013604 abnormal adult Leydig cell differentiation "atypical formation of or inability to produce the second or adult population of Leydig cells (ALCs) between birth and puberty; ALCs arise in the interstitium of adult testes from unknown progenitor cells and become the major source of androgens that control differentiation of the male reproductive tract and spermatogenesis; ALCs are not derived from fetal Leydig cells (FLCs), and the origin and the molecular events that control ALC differentiation are poorly understood" [PMID:23568777]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Sirt1tm1Mcby/Sirt1tm1Mcby
Genetic Background: 129/Sv-Sirt1tm1Mcby

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033712 Ccar2 / Q8VDP4 / Cell cycle and apoptosis regulator protein 2 / Q8N163* / cell cycle and apoptosis regulator 2*  / reaction / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / reaction / complex
 ENSMUSG00000039231 O54864 / Suv39h1 / suppressor of variegation 3-9 1 / O43463* / suppressor of variegation 3-9 homolog 1*  / reaction / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / complex / reaction
 ENSMUSG00000030888 Rrp8 / Q9DB85 / Ribosomal RNA-processing protein 8 / O43159* / ribosomal RNA processing 8*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / reaction / complex
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction / complex
 ENSMUSG00000005483 Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*  / complex / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex / reaction






 

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