ENSGALG00000002761


Gallus gallus

Features
Gene ID: ENSGALG00000002761
  
Biological name :SIRT1
  
Synonyms : NAD-dependent protein deacetylase sirtuin-1 / SIRT1
  
Possible biological names infered from orthology : NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q923E4 / Q96EB6 / sirtuin 1
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 6640858
Gene end: 6662304
  
Corresponding Affymetrix probe sets: Gga.11206.1.A1_at (Chicken Array)   Gga.11206.1.S1_at (Chicken Array)   GgaAffx.1802.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046837
Ensembl peptide - ENSGALP00000004350
NCBI entrez gene - 423646     See in Manteia.
RefSeq - XM_015288092
RefSeq - XM_015288089
RefSeq - XM_015288090
RefSeq - XM_015288091
RefSeq - NM_001004767
RefSeq Peptide - NP_001004767
swissprot - F1N886
swissprot - A0A1D5P2E2
Ensembl - ENSGALG00000002761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt1ENSDARG00000068064Danio rerio
 SIRT1ENSG00000096717Homo sapiens
 Sirt1ENSMUSG00000020063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT4 / sirtuin 4 / Q8R216* / Q9Y6E7* / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial *ENSGALG0000000724410
SIRT5 / E1BRE2 / NAD-dependent protein deacylase sirtuin-5, mitochondrial / Q8K2C6* / Q9NXA8* / sirtuin 5*ENSGALG000000126929


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000183 chromatin silencing at rDNA IEA
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair IEA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002821 positive regulation of adaptive immune response IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006343 establishment of chromatin silencing IEA
 biological_processGO:0006344 maintenance of chromatin silencing IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0006642 triglyceride mobilization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010875 positive regulation of cholesterol efflux IEA
 biological_processGO:0010883 regulation of lipid storage IEA
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0010934 macrophage cytokine production IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0018394 peptidyl-lysine acetylation IEA
 biological_processGO:0030225 macrophage differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0031393 negative regulation of prostaglandin biosynthetic process IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0031937 positive regulation of chromatin silencing IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0035356 cellular triglyceride homeostasis IEA
 biological_processGO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042595 behavioral response to starvation IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050872 white fat cell differentiation IEA
 biological_processGO:0051097 negative regulation of helicase activity IEA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0055089 fatty acid homeostasis IEA
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IEA
 biological_processGO:0061647 histone H3-K9 modification IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070857 regulation of bile acid biosynthetic process IEA
 biological_processGO:0070914 UV-damage excision repair IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071441 negative regulation of histone H3-K14 acetylation IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0090335 regulation of brown fat cell differentiation IEA
 biological_processGO:0090400 stress-induced premature senescence IEA
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901984 negative regulation of protein acetylation IEA
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IEA
 biological_processGO:1990619 histone H3-K9 deacetylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000111 positive regulation of macrophage apoptotic process IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IEA
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IEA
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation IEA
 biological_processGO:2000655 negative regulation of cellular response to testosterone stimulus IEA
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 biological_processGO:2000774 positive regulation of cellular senescence IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005677 chromatin silencing complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005720 nuclear heterochromatin IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0033553 rDNA heterochromatin IEA
 cellular_componentGO:0035098 ESC/E(Z) complex IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0019213 deacetylase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043398 HLH domain binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA
 molecular_functionGO:1990254 keratin filament binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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