ENSDARG00000068064


Danio rerio

Features
Gene ID: ENSDARG00000068064
  
Biological name :sirt1
  
Synonyms : sirt1 / sirtuin 1
  
Possible biological names infered from orthology : NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q923E4 / Q96EB6
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 50345345
Gene end: 50366950
  
Corresponding Affymetrix probe sets: Dr.10536.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000088981
NCBI entrez gene - 797132     See in Manteia.
swissprot - E7F8W3
ZFIN ID - ZDB-GENE-070801-2
Ensembl - ENSDARG00000068064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIRT1ENSGALG00000002761Gallus gallus
 SIRT1ENSG00000096717Homo sapiens
 Sirt1ENSMUSG00000020063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sirt5 / Q6DHI5 / sirtuin 5 / Q8K2C6* / Q9NXA8* / NAD-dependent protein deacylase sirtuin-5, mitochondrial *ENSDARG0000003968411
sirt4 / sirtuin 4 / Q8R216* / Q9Y6E7* / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial *ENSDARG0000001041510


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0014013 regulation of gliogenesis IMP
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0001079 blood vasculature blood vasculature hemorrhagic , abnormal
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 ZFA:0001115 trunk trunk glial cell projection mislocalised , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel structure , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature spatial pattern , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026799 Q6DGD3 / suv39h1a / suppressor of variegation 3-9 homolog 1a / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*  / reaction / complex
 ENSDARG00000008818 hsf1 / heat shock transcription factor 1 / P38532* / Q00613* / heat shock factor 1*  / reaction / complex
 ENSDARG00000055753 suv39h1b / suppressor of variegation 3-9 homolog 1b / O54864* / O43463* / SUV39H1* / suppressor of variegation 3-9 1* / suppressor of variegation 3-9 homolog 1*  / complex / reaction
 ENSDARG00000068436 Q6PI20 / h3f3b.1 / H3 histone, family 3B.1 / H3F3B* / H3F3C* / P84243* / Q6NXT2* / H3 histone family member 3C* / H3 histone family member 3B*  / reaction / complex
 ENSDARG00000105345 zgc:173552  / reaction / complex
 ENSDARG00000105359 Q4QRF4 / FP325123.1 / Histone H3.2   / reaction / complex
 ENSDARG00000038302 ccar2 / cell cycle and apoptosis regulator 2 / Q8N163* / Q8VDP4* / Cell cycle and apoptosis regulator protein 2 *  / reaction / complex
 ENSDARG00000071652 rrp8 / ribosomal RNA processing 8, methyltransferase, homolog (yeast) / O43159* / Q9DB85* / ribosomal RNA processing 8* / Ribosomal RNA-processing protein 8 *  / complex / reaction






 

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