ENSG00000096717


Homo sapiens

Features
Gene ID: ENSG00000096717
  
Biological name :SIRT1
  
Synonyms : Q96EB6 / SIRT1 / sirtuin 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q21.3
Gene start: 67884669
Gene end: 67918390
  
Corresponding Affymetrix probe sets: 218878_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000212015
Ensembl peptide - ENSP00000409208
Ensembl peptide - ENSP00000384508
Ensembl peptide - ENSP00000384063
NCBI entrez gene - 23411     See in Manteia.
OMIM - 604479
RefSeq - NM_001142498
RefSeq - NM_001314049
RefSeq - NM_012238
RefSeq Peptide - NP_001300978
RefSeq Peptide - NP_036370
RefSeq Peptide - NP_001135970
swissprot - Q96EB6
swissprot - B0QZ35
swissprot - A0A024QZQ1
swissprot - E9PC49
Ensembl - ENSG00000096717
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt1ENSDARG00000068064Danio rerio
 SIRT1ENSGALG00000002761Gallus gallus
 Sirt1ENSMUSG00000020063Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT5 / Q9NXA8 / sirtuin 5ENSG0000012452310
SIRT4 / Q9Y6E7 / sirtuin 4ENSG0000008916310


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IMP
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair IMP
 biological_processGO:0000731 DNA synthesis involved in DNA repair ISS
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001678 cellular glucose homeostasis ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002821 positive regulation of adaptive immune response IDA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006325 chromatin organization IMP
 biological_processGO:0006342 chromatin silencing TAS
 biological_processGO:0006343 establishment of chromatin silencing IDA
 biological_processGO:0006344 maintenance of chromatin silencing IMP
 biological_processGO:0006346 methylation-dependent chromatin silencing TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006476 protein deacetylation TAS
 biological_processGO:0006642 triglyceride mobilization ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IDA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007569 cell aging TAS
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010875 positive regulation of cholesterol efflux ISS
 biological_processGO:0010883 regulation of lipid storage ISS
 biological_processGO:0010906 regulation of glucose metabolic process ISS
 biological_processGO:0010934 macrophage cytokine production ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016239 positive regulation of macroautophagy IDA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0016575 histone deacetylation IDA
 biological_processGO:0018394 peptidyl-lysine acetylation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030225 macrophage differentiation ISS
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0031393 negative regulation of prostaglandin biosynthetic process ISS
 biological_processGO:0031648 protein destabilization ISS
 biological_processGO:0031937 positive regulation of chromatin silencing IMP
 biological_processGO:0032007 negative regulation of TOR signaling IMP
 biological_processGO:0032071 regulation of endodeoxyribonuclease activity IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032868 response to insulin ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IMP
 biological_processGO:0033210 leptin-mediated signaling pathway ISS
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process ISS
 biological_processGO:0034983 peptidyl-lysine deacetylation IDA
 biological_processGO:0035356 cellular triglyceride homeostasis ISS
 biological_processGO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway ISS
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042326 negative regulation of phosphorylation IMP
 biological_processGO:0042542 response to hydrogen peroxide IDA
 biological_processGO:0042595 behavioral response to starvation IEA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0044321 response to leptin ISS
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050872 white fat cell differentiation ISS
 biological_processGO:0051097 negative regulation of helicase activity IDA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0055089 fatty acid homeostasis ISS
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway IMP
 biological_processGO:0061647 histone H3-K9 modification IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0070857 regulation of bile acid biosynthetic process ISS
 biological_processGO:0070914 UV-damage excision repair IMP
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071441 negative regulation of histone H3-K14 acetylation IMP
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0071479 cellular response to ionizing radiation ISS
 biological_processGO:0071900 regulation of protein serine/threonine kinase activity IMP
 biological_processGO:0090335 regulation of brown fat cell differentiation ISS
 biological_processGO:0090400 stress-induced premature senescence IMP
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901984 negative regulation of protein acetylation IMP
 biological_processGO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1904179 positive regulation of adipose tissue development ISS
 biological_processGO:1990619 histone H3-K9 deacetylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000111 positive regulation of macrophage apoptotic process ISS
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IDA
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity IMP
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation IMP
 biological_processGO:2000655 negative regulation of cellular response to testosterone stimulus IMP
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IDA
 biological_processGO:2000773 negative regulation of cellular senescence IDA
 biological_processGO:2000774 positive regulation of cellular senescence IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005637 nuclear inner membrane IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IDA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0033553 rDNA heterochromatin IDA
 cellular_componentGO:0035098 ESC/E(Z) complex IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0004407 histone deacetylase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IDA
 molecular_functionGO:0019213 deacetylase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IMP
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0042393 histone binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043398 HLH domain binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) ISS
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IPI
 molecular_functionGO:0070403 NAD+ binding IEA
 molecular_functionGO:1990254 keratin filament binding IPI


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
Circadian Clock
SIRT1 negatively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / complex / reaction
 ENSG00000101945 O43463 / SUV39H1 / suppressor of variegation 3-9 homolog 1  / reaction / complex
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / reaction / complex
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / complex / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction
 ENSG00000132275 RRP8 / O43159 / ribosomal RNA processing 8  / reaction / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000158941 CCAR2 / Q8N163 / cell cycle and apoptosis regulator 2  / complex / reaction






 

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