ENSG00000089163


Homo sapiens

Features
Gene ID: ENSG00000089163
  
Biological name :SIRT4
  
Synonyms : Q9Y6E7 / SIRT4 / sirtuin 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 120302316
Gene end: 120313249
  
Corresponding Affymetrix probe sets: 220047_at (Human Genome U133 Plus 2.0 Array)   222248_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000202967
Ensembl peptide - ENSP00000444838
NCBI entrez gene - 23409     See in Manteia.
OMIM - 604482
RefSeq - XM_006719309
RefSeq - NM_012240
RefSeq - XM_005253865
RefSeq - XM_006719308
RefSeq Peptide - NP_036372
swissprot - F5H4X9
swissprot - Q9Y6E7
Ensembl - ENSG00000089163
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt4ENSDARG00000010415Danio rerio
 SIRT4ENSGALG00000007244Gallus gallus
 Sirt4ENSMUSG00000029524Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT1 / Q96EB6 / sirtuin 1ENSG0000009671725
SIRT5 / Q9NXA8 / sirtuin 5ENSG0000012452325


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026587  Sirtuin, class II
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000820 regulation of glutamine family amino acid metabolic process IEA
 biological_processGO:0006342 chromatin silencing TAS
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072350 tricarboxylic acid metabolic process IEA
 biological_processGO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion IEA
 biological_processGO:1904182 regulation of pyruvate dehydrogenase activity IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047708 biotinidase activity IDA
 molecular_functionGO:0061690 lipoamidase activity IDA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148672 GLUD1 / P00367 / glutamate dehydrogenase 1  / reaction






 

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