ENSMUSG00000029524


Mus musculus

Features
Gene ID: ENSMUSG00000029524
  
Biological name :Sirt4
  
Synonyms : NAD-dependent protein lipoamidase sirtuin-4, mitochondrial / Q8R216 / Sirt4
  
Possible biological names infered from orthology : Q9Y6E7 / sirtuin 4
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 115478010
Gene end: 115484725
  
Corresponding Affymetrix probe sets: 10532999 (MoGene1.0st)   1426847_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107697
Ensembl peptide - ENSMUSP00000107698
NCBI entrez gene - 75387     See in Manteia.
MGI - MGI:1922637
RefSeq - XM_017321127
RefSeq - NM_001167691
RefSeq - NM_133760
RefSeq - XM_006530482
RefSeq - XM_006530483
RefSeq - XM_006530485
RefSeq - XM_006530479
RefSeq - XM_006530480
RefSeq - XM_006530481
RefSeq Peptide - NP_598521
RefSeq Peptide - NP_001161163
swissprot - Q8R216
Ensembl - ENSMUSG00000029524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt4ENSDARG00000010415Danio rerio
 SIRT4ENSGALG00000007244Gallus gallus
 SIRT4ENSG00000089163Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*ENSMUSG0000002006324
Sirt5 / Q8K2C6 / NAD-dependent protein deacylase sirtuin-5, mitochondrial / Q9NXA8* / sirtuin 5*ENSMUSG0000005402123


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026587  Sirtuin, class II
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000820 regulation of glutamine family amino acid metabolic process IMP
 biological_processGO:0006471 protein ADP-ribosylation IMP
 biological_processGO:0006541 glutamine metabolic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IDA
 biological_processGO:0046322 negative regulation of fatty acid oxidation IEA
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process IDA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072350 tricarboxylic acid metabolic process IMP
 biological_processGO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion IEA
 biological_processGO:1904182 regulation of pyruvate dehydrogenase activity IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047708 biotinidase activity IEA
 molecular_functionGO:0061690 lipoamidase activity IMP
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shhtm1b(EUCOMM)Wtsi/Shhtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Shhtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021794 Glud1 / P26443 / Glutamate dehydrogenase 1, mitochondrial / GLUD2* / P00367* / P49448* / glutamate dehydrogenase 1* / glutamate dehydrogenase 2*  / reaction






 

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