ENSMUSG00000021794


Mus musculus

Features
Gene ID: ENSMUSG00000021794
  
Biological name :Glud1
  
Synonyms : Glud1 / Glutamate dehydrogenase 1, mitochondrial / P26443
  
Possible biological names infered from orthology : GLUD2 / glutamate dehydrogenase 1 / glutamate dehydrogenase 2 / P00367 / P49448
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 34310727
Gene end: 34345265
  
Corresponding Affymetrix probe sets: 10414093 (MoGene1.0st)   1416209_at (Mouse Genome 430 2.0 Array)   1448253_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022322
Ensembl peptide - ENSMUSP00000130934
NCBI entrez gene - 14661     See in Manteia.
MGI - MGI:95753
RefSeq - NM_008133
RefSeq Peptide - NP_032159
swissprot - F7CFA5
swissprot - P26443
Ensembl - ENSMUSG00000021794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glud1aENSDARG00000008816Danio rerio
 glud1bENSDARG00000101074Danio rerio
 ENSGALG00000034735Gallus gallus
 GLUD1ENSG00000148672Homo sapiens
 GLUD2ENSG00000182890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006095  Glutamate/phenylalanine/leucine/valine dehydrogenase
 IPR006096  Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
 IPR006097  Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
 IPR033524  Leu/Phe/Val dehydrogenases active site
 IPR033922  NAD(P) binding domain of glutamate dehydrogenase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006537 glutamate biosynthetic process ISO
 biological_processGO:0006538 glutamate catabolic process ISO
 biological_processGO:0006541 glutamine metabolic process IMP
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0010044 response to aluminum ion IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0032024 positive regulation of insulin secretion ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072350 tricarboxylic acid metabolic process IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004352 glutamate dehydrogenase (NAD+) activity IEA
 molecular_functionGO:0004353 glutamate dehydrogenase [NAD(P)+] activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043531 ADP binding ISO
 molecular_functionGO:0070403 NAD+ binding ISO
 molecular_functionGO:0070728 leucine binding ISO


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

Allelic Composition: Glud1tm1.1Pma/Glud1tm1.1Pma
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorbm1Btlr/Rorbm1Btlr
Genetic Background: C57BL/6J-Rorbm1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021794 Glud1 / P26443 / Glutamate dehydrogenase 1, mitochondrial / GLUD2* / P00367* / P49448* / glutamate dehydrogenase 1* / glutamate dehydrogenase 2*  / complex
 ENSMUSG00000025486 Sirt3 / Q8R104 / sirtuin 3 / Q9NTG7*  / reaction
 ENSMUSG00000029524 Sirt4 / Q8R216 / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial / Q9Y6E7* / sirtuin 4*  / reaction






 

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