ENSMUSG00000025486


Mus musculus

Features
Gene ID: ENSMUSG00000025486
  
Biological name :Sirt3
  
Synonyms : Q8R104 / Sirt3 / sirtuin 3
  
Possible biological names infered from orthology : Q9NTG7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 140863666
Gene end: 140882309
  
Corresponding Affymetrix probe sets: 10568997 (MoGene1.0st)   1417892_a_at (Mouse Genome 430 2.0 Array)   1445729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101663
Ensembl peptide - ENSMUSP00000147716
Ensembl peptide - ENSMUSP00000147504
Ensembl peptide - ENSMUSP00000121151
Ensembl peptide - ENSMUSP00000115202
Ensembl peptide - ENSMUSP00000114247
Ensembl peptide - ENSMUSP00000026559
NCBI entrez gene - 64384     See in Manteia.
MGI - MGI:1927665
RefSeq - XM_006536223
RefSeq - NM_001127351
RefSeq - NM_001177804
RefSeq - NM_022433
RefSeq - XM_006536222
RefSeq Peptide - NP_001171275
RefSeq Peptide - NP_071878
RefSeq Peptide - NP_001120823
swissprot - D3YTK6
swissprot - A0A1B0GRY5
swissprot - A0A1B0GRF7
swissprot - Q4FJK3
swissprot - D3YVQ5
swissprot - Q8R104
swissprot - D3YWD6
Ensembl - ENSMUSG00000025486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt3ENSDARG00000035819Danio rerio
 SIRT3ENSGALG00000032496Gallus gallus
 SIRT3ENSG00000142082Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt2 / Q8VDQ8 / NAD-dependent protein deacetylase sirtuin-2 / Q8IXJ6* / sirtuin 2*ENSMUSG0000001514953


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation ISS
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:1903109 positive regulation of mitochondrial transcription IMP
 biological_processGO:2000757 negative regulation of peptidyl-lysine acetylation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scd1tm1Ntam/Scd1tm1Ntam,Sirt3tm1.1Fwa/Sirt3tm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scd1tm1Ntam/Scd1tm1Ntam,Sirt3tm1.1Fwa/Sirt3tm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006818 Sod2 / P09671 / superoxide dismutase 2, mitochondrial / P04179* / superoxide dismutase 2*  / reaction
 ENSMUSG00000027605 Acss2 / Q9QXG4 / Acetyl-coenzyme A synthetase, cytoplasmic / Q9NR19* / acyl-CoA synthetase short chain family member 2*  / reaction
 ENSMUSG00000021794 Glud1 / P26443 / Glutamate dehydrogenase 1, mitochondrial / GLUD2* / P00367* / P49448* / glutamate dehydrogenase 1* / glutamate dehydrogenase 2*  / reaction
 ENSMUSG00000030541 Idh2 / P54071 / Isocitrate dehydrogenase [NADP], mitochondrial / P48735* / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*  / reaction






 

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