ENSMUSG00000030541


Mus musculus

Features
Gene ID: ENSMUSG00000030541
  
Biological name :Idh2
  
Synonyms : Idh2 / Isocitrate dehydrogenase [NADP], mitochondrial / P54071
  
Possible biological names infered from orthology : isocitrate dehydrogenase (NADP(+)) 2, mitochondrial / P48735
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80094846
Gene end: 80115392
  
Corresponding Affymetrix probe sets: 10564857 (MoGene1.0st)   1450048_a_at (Mouse Genome 430 2.0 Array)   1453601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103007
Ensembl peptide - ENSMUSP00000146084
Ensembl peptide - ENSMUSP00000145852
Ensembl peptide - ENSMUSP00000118184
NCBI entrez gene - 269951     See in Manteia.
MGI - MGI:96414
RefSeq - NM_173011
RefSeq Peptide - NP_766599
swissprot - A0A0U1RPR1
swissprot - A0A0U1RP68
swissprot - D6RIL6
swissprot - P54071
Ensembl - ENSMUSG00000030541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 idh2ENSDARG00000003795Danio rerio
 IDH2ENSGALG00000034434Gallus gallus
 IDH2ENSG00000182054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Idh1 / O88844 / Isocitrate dehydrogenase [NADP] cytoplasmic / O75874* / isocitrate dehydrogenase (NADP(+)) 1, cytosolic*ENSMUSG0000002595062


Protein motifs (from Interpro)
Interpro ID Name
 IPR004790  Isocitrate dehydrogenase NADP-dependent
 IPR019818  Isocitrate/isopropylmalate dehydrogenase, conserved site
 IPR024084  Isopropylmalate dehydrogenase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006097 glyoxylate cycle IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006102 isocitrate metabolic process IEA
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006741 NADP biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060253 negative regulation of glial cell proliferation IEA
 biological_processGO:1903976 negative regulation of glial cell migration IEA
 biological_processGO:1904465 negative regulation of matrix metallopeptidase secretion IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004448 isocitrate dehydrogenase activity IDA
 molecular_functionGO:0004450 isocitrate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025486 Sirt3 / Q8R104 / sirtuin 3 / Q9NTG7*  / reaction
 ENSMUSG00000030541 Idh2 / P54071 / Isocitrate dehydrogenase [NADP], mitochondrial / P48735* / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*  / complex






 

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