ENSDARG00000003795


Danio rerio

Features
Gene ID: ENSDARG00000003795
  
Biological name :idh2
  
Synonyms : idh2 / isocitrate dehydrogenase 2 (NADP+), mitochondrial
  
Possible biological names infered from orthology : isocitrate dehydrogenase (NADP(+)) 2, mitochondrial / Isocitrate dehydrogenase [NADP], mitochondrial / P48735 / P54071
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 26096814
Gene end: 26101800
  
Corresponding Affymetrix probe sets: Dr.5525.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000027389
swissprot - E7F4R9
ZFIN ID - ZDB-GENE-031118-95
Ensembl - ENSDARG00000003795
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IDH2ENSGALG00000034434Gallus gallus
 IDH2ENSG00000182054Homo sapiens
 Idh2ENSMUSG00000030541Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
idh1 / isocitrate dehydrogenase 1 (NADP+), soluble / O75874* / isocitrate dehydrogenase (NADP(+)) 1, cytosolic*ENSDARG0000002537567


Protein motifs (from Interpro)
Interpro ID Name
 IPR004790  Isocitrate dehydrogenase NADP-dependent
 IPR024084  Isopropylmalate dehydrogenase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006102 isocitrate metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004450 isocitrate dehydrogenase (NADP+) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003795 idh2 / isocitrate dehydrogenase 2 (NADP+), mitochondrial / P48735* / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*  / complex
 ENSDARG00000035819 sirt3 / sirtuin 3 / Q8R104* / Q9NTG7*  / reaction






 

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