ENSMUSG00000025950


Mus musculus

Features
Gene ID: ENSMUSG00000025950
  
Biological name :Idh1
  
Synonyms : Idh1 / Isocitrate dehydrogenase [NADP] cytoplasmic / O88844
  
Possible biological names infered from orthology : isocitrate dehydrogenase (NADP(+)) 1, cytosolic / O75874
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C2
Gene start: 65158616
Gene end: 65186500
  
Corresponding Affymetrix probe sets: 10355214 (MoGene1.0st)   1419821_s_at (Mouse Genome 430 2.0 Array)   1422433_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117853
Ensembl peptide - ENSMUSP00000140757
Ensembl peptide - ENSMUSP00000140694
Ensembl peptide - ENSMUSP00000139906
Ensembl peptide - ENSMUSP00000139430
Ensembl peptide - ENSMUSP00000127307
Ensembl peptide - ENSMUSP00000095316
NCBI entrez gene - 15926     See in Manteia.
MGI - MGI:96413
RefSeq - NM_001111320
RefSeq - NM_010497
RefSeq Peptide - NP_001104790
RefSeq Peptide - NP_034627
swissprot - D3YVY3
swissprot - O88844
swissprot - A0A087WRS9
swissprot - A0A087WRM4
swissprot - A0A087WPT4
swissprot - A0A087WNN7
Ensembl - ENSMUSG00000025950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 idh1ENSDARG00000025375Danio rerio
 IDH1ENSGALG00000008818Gallus gallus
 IDH1ENSG00000138413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Idh2 / P54071 / Isocitrate dehydrogenase [NADP], mitochondrial / P48735* / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial*ENSMUSG0000003054168


Protein motifs (from Interpro)
Interpro ID Name
 IPR004790  Isocitrate dehydrogenase NADP-dependent
 IPR019818  Isocitrate/isopropylmalate dehydrogenase, conserved site
 IPR024084  Isopropylmalate dehydrogenase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006097 glyoxylate cycle IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006102 isocitrate metabolic process ISO
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0008585 female gonad development IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060696 regulation of phospholipid catabolic process IMP
 biological_processGO:0071071 regulation of phospholipid biosynthetic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004448 isocitrate dehydrogenase activity IDA
 molecular_functionGO:0004450 isocitrate dehydrogenase (NADP+) activity ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity ISO


Pathways (from Reactome)
Pathway description
NADPH regeneration
Neutrophil degranulation
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Idh1tm3Mak/Idh1+,Tg(Col2a1-cre/ERT2)1Dic/0
Genetic Background: involves: C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lgr4tm1.2Knis/Lgr4tm1.2Knis
Genetic Background: B6.129P2-Lgr4tm1.2Knis

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Idh1tm1Mak/Idh1tm1Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Idh1tm2Mak/Idh1tm2Mak,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0012514 pectus excavatum "a caved-in or sunken appearance of the anterior chest wall; the congenital deformity can either be present at birth or may not be visible until puberty" [MGI:anna]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm1Gev/Trp53tm1Gev
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025950 Idh1 / O88844 / Isocitrate dehydrogenase [NADP] cytoplasmic / O75874* / isocitrate dehydrogenase (NADP(+)) 1, cytosolic*  / complex






 

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