ENSMUSG00000015149


Mus musculus

Features
Gene ID: ENSMUSG00000015149
  
Biological name :Sirt2
  
Synonyms : NAD-dependent protein deacetylase sirtuin-2 / Q8VDQ8 / Sirt2
  
Possible biological names infered from orthology : Q8IXJ6 / sirtuin 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 28766735
Gene end: 28788661
  
Corresponding Affymetrix probe sets: 10551570 (MoGene1.0st)   1423507_a_at (Mouse Genome 430 2.0 Array)   1431100_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072732
Ensembl peptide - ENSMUSP00000132783
Ensembl peptide - ENSMUSP00000146462
Ensembl peptide - ENSMUSP00000147217
NCBI entrez gene - 64383     See in Manteia.
MGI - MGI:1927664
RefSeq - XM_017312217
RefSeq - NM_001122765
RefSeq - NM_001122766
RefSeq - NM_022432
RefSeq - XM_017312214
RefSeq - XM_017312215
RefSeq - XM_017312216
RefSeq Peptide - NP_001116237
RefSeq Peptide - NP_001116238
RefSeq Peptide - NP_071877
swissprot - Q8VDQ8
swissprot - A0A140LHL5
Ensembl - ENSMUSG00000015149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt2ENSDARG00000011488Danio rerio
 SIRT2ENSGALG00000029761Gallus gallus
 SIRT2ENSG00000068903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt3 / Q8R104 / sirtuin 3 / Q9NTG7*ENSMUSG0000002548635


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006476 protein deacetylation ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010507 negative regulation of autophagy ISS
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031641 regulation of myelination IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0034599 cellular response to oxidative stress IDA
 biological_processGO:0034983 peptidyl-lysine deacetylation ISS
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus ISS
 biological_processGO:0042177 negative regulation of protein catabolic process ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043491 protein kinase B signaling ISO
 biological_processGO:0044242 cellular lipid catabolic process IMP
 biological_processGO:0045598 regulation of fat cell differentiation IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045836 positive regulation of meiotic nuclear division IMP
 biological_processGO:0045843 negative regulation of striated muscle tissue development ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0051781 positive regulation of cell division IMP
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore IMP
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ISS
 biological_processGO:0061433 cellular response to caloric restriction IDA
 biological_processGO:0070446 negative regulation of oligodendrocyte progenitor proliferation ISS
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:0070933 histone H4 deacetylation ISS
 biological_processGO:0071219 cellular response to molecule of bacterial origin ISS
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0071872 cellular response to epinephrine stimulus IDA
 biological_processGO:0090042 tubulin deacetylation ISO
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IMP
 biological_processGO:1900195 positive regulation of oocyte maturation IMP
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IMP
 biological_processGO:1900425 negative regulation of defense response to bacterium ISO
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome ISO
 cellular_componentGO:0005720 nuclear heterochromatin ISS
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005814 centriole ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0033010 paranodal junction IDA
 cellular_componentGO:0033270 paranode region of axon ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043219 lateral loop ISS
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IDA
 cellular_componentGO:0044224 juxtaparanode region of axon ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0072686 mitotic spindle ISS
 cellular_componentGO:0072687 meiotic spindle IDA
 cellular_componentGO:0097386 glial cell projection ISS
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity ISO
 molecular_functionGO:0035035 histone acetyltransferase binding ISS
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0042903 tubulin deacetylase activity ISO
 molecular_functionGO:0043130 ubiquitin binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) ISO
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn/Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn/Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sirt2tm1a(EUCOMM)Wtsi/Sirt2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn/Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn/Gt(ROSA)26Sortm11(CAG-Braf*/ERT2)Rkuhn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Sirt2tm1.1Fwa/Sirt2tm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm1.1Otin/Lmnatm1.1Otin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Hdac6tm1Pmt/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sirt2tm1.1Fwa/Sirt2tm1.1Fwa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Jam3tm1Rha/Jam3tm1.1Chav,Tg(Spo11-cre)D5Mpel/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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