ENSG00000068903


Homo sapiens

Features
Gene ID: ENSG00000068903
  
Biological name :SIRT2
  
Synonyms : Q8IXJ6 / SIRT2 / sirtuin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 38878555
Gene end: 38899862
  
Corresponding Affymetrix probe sets: 1558331_at (Human Genome U133 Plus 2.0 Array)   220605_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385146
Ensembl peptide - ENSP00000481932
Ensembl peptide - ENSP00000411393
Ensembl peptide - ENSP00000409690
Ensembl peptide - ENSP00000408023
Ensembl peptide - ENSP00000407272
Ensembl peptide - ENSP00000404309
Ensembl peptide - ENSP00000401203
Ensembl peptide - ENSP00000400338
Ensembl peptide - ENSP00000397022
Ensembl peptide - ENSP00000249396
Ensembl peptide - ENSP00000351809
Ensembl peptide - ENSP00000375931
NCBI entrez gene - 22933     See in Manteia.
OMIM - 604480
RefSeq - NM_012237
RefSeq - NM_030593
RefSeq - NM_001193286
RefSeq - XM_011526654
RefSeq - XM_011526655
RefSeq - XM_017026500
RefSeq - XM_006723111
RefSeq Peptide - NP_036369
RefSeq Peptide - NP_085096
RefSeq Peptide - NP_001180215
swissprot - E7EWX6
swissprot - Q8IXJ6
swissprot - F8WF57
swissprot - C9JZQ0
swissprot - C9JR33
swissprot - C9J3U7
swissprot - B5MCS1
swissprot - A0A0A0MRF5
swissprot - A0A087WYM3
swissprot - A0A024R0G8
swissprot - F8WBT6
swissprot - F8WCF4
swissprot - F8WDM4
Ensembl - ENSG00000068903
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt2ENSDARG00000011488Danio rerio
 SIRT2ENSGALG00000029761Gallus gallus
 Sirt2ENSMUSG00000015149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT3 / Q9NTG7 / sirtuin 3ENSG0000014208239


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000183 chromatin silencing at rDNA NAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006342 chromatin silencing NAS
 biological_processGO:0006348 chromatin silencing at telomere NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006471 protein ADP-ribosylation NAS
 biological_processGO:0006476 protein deacetylation IMP
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007096 regulation of exit from mitosis NAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016458 gene silencing NAS
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0022011 myelination in peripheral nervous system ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031641 regulation of myelination ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0034599 cellular response to oxidative stress ISS
 biological_processGO:0034983 peptidyl-lysine deacetylation IDA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042325 regulation of phosphorylation NAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0044242 cellular lipid catabolic process ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045836 positive regulation of meiotic nuclear division ISS
 biological_processGO:0045843 negative regulation of striated muscle tissue development IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051775 response to redox state NAS
 biological_processGO:0051781 positive regulation of cell division ISS
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore ISS
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0061433 cellular response to caloric restriction ISS
 biological_processGO:0070446 negative regulation of oligodendrocyte progenitor proliferation ISS
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:0070933 histone H4 deacetylation IDA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0071872 cellular response to epinephrine stimulus ISS
 biological_processGO:0090042 tubulin deacetylation ISS
 biological_processGO:1900119 positive regulation of execution phase of apoptosis ISS
 biological_processGO:1900195 positive regulation of oocyte maturation ISS
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1900425 negative regulation of defense response to bacterium IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process ISS
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005677 chromatin silencing complex NAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005720 nuclear heterochromatin ISS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0033010 paranodal junction ISS
 cellular_componentGO:0033270 paranode region of axon ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0043209 myelin sheath ISS
 cellular_componentGO:0043219 lateral loop ISS
 cellular_componentGO:0043220 Schmidt-Lanterman incisure ISS
 cellular_componentGO:0044224 juxtaparanode region of axon ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0072687 meiotic spindle ISS
 cellular_componentGO:0097386 glial cell projection ISS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004407 histone deacetylase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IMP
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0042903 tubulin deacetylase activity IDA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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