22933


Homo sapiens (NCBI)

Features
Gene ID: 22933
  
Biological name :
  
Synonyms : SIR2|SIR2L|SIR2L2 / SIRT2 / sirtuin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1558331_at (Human Genome U133 Plus 2.0 Array)   220605_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034606864
RefSeq - 13775600
RefSeq - 13775602
RefSeq - 300797705
RefSeq - 578834181
RefSeq - 768007548
RefSeq - 768007552
RefSeq - NC_000019.10
RefSeq - NP_001180215.1
RefSeq - NP_036369.2
RefSeq - NP_085096.1
RefSeq - NW_014040929.1
RefSeq - XP_006723174.1
RefSeq - XP_011524956.1
RefSeq - XP_011524957.1
RefSeq - XP_016881989.1
RefSeq - XM_006723111.1
RefSeq - XM_011526654.2
RefSeq - NM_001193286.1
RefSeq - NM_012237.3
RefSeq - NM_030593.2
RefSeq - XM_011526655.1
RefSeq - XM_017026500.1
RefSeq - XR_001753638.2
RefSeq - NR_034146.1
RefSeq - XR_001753639.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000068903 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000183 chromatin silencing at rDNA NAS
 biological_processGO:0006342 chromatin silencing NAS
 biological_processGO:0006348 chromatin silencing at telomere NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006471 protein ADP-ribosylation TAS
 biological_processGO:0006476 protein deacetylation IMP
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007096 regulation of exit from mitosis NAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016458 gene silencing NAS
 biological_processGO:0016575 histone deacetylation TAS
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0022011 myelination in peripheral nervous system ISS
 biological_processGO:0031641 regulation of myelination ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0034599 cellular response to oxidative stress ISS
 biological_processGO:0034983 peptidyl-lysine deacetylation IDA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IDA
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0042325 regulation of phosphorylation NAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0044242 cellular lipid catabolic process ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045836 positive regulation of meiotic nuclear division ISS
 biological_processGO:0045843 negative regulation of striated muscle tissue development IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051775 response to redox state NAS
 biological_processGO:0051781 positive regulation of cell division ISS
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore ISS
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
 biological_processGO:0061433 cellular response to caloric restriction ISS
 biological_processGO:0070446 negative regulation of oligodendrocyte progenitor proliferation ISS
 biological_processGO:0070932 histone H3 deacetylation IMP
 biological_processGO:0070933 histone H4 deacetylation IDA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IDA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0071872 cellular response to epinephrine stimulus ISS
 biological_processGO:0090042 tubulin deacetylation ISS
 biological_processGO:1900119 positive regulation of execution phase of apoptosis ISS
 biological_processGO:1900195 positive regulation of oocyte maturation ISS
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1900425 negative regulation of defense response to bacterium IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process ISS
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005677 chromatin silencing complex NAS
 cellular_componentGO:0005694 chromosome IDA
 cellular_componentGO:0005720 nuclear heterochromatin ISS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0033010 paranodal junction ISS
 cellular_componentGO:0033270 paranode region of axon ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0043209 myelin sheath ISS
 cellular_componentGO:0043219 lateral loop ISS
 cellular_componentGO:0043220 Schmidt-Lanterman incisure ISS
 cellular_componentGO:0044224 juxtaparanode region of axon ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0072686 mitotic spindle IDA
 cellular_componentGO:0072687 meiotic spindle ISS
 cellular_componentGO:0097386 glial cell projection ISS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0004407 histone deacetylase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IDA
 molecular_functionGO:0033558 protein deacetylase activity IMP
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IMP
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0042903 tubulin deacetylase activity IDA
 molecular_functionGO:0043130 ubiquitin binding IDA
 molecular_functionGO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
 molecular_functionGO:0070403 NAD+ binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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