ENSG00000142082


Homo sapiens

Features
Gene ID: ENSG00000142082
  
Biological name :SIRT3
  
Synonyms : Q9NTG7 / SIRT3 / sirtuin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 215458
Gene end: 236931
  
Corresponding Affymetrix probe sets: 221562_s_at (Human Genome U133 Plus 2.0 Array)   221913_at (Human Genome U133 Plus 2.0 Array)   49327_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432937
Ensembl peptide - ENSP00000437216
Ensembl peptide - ENSP00000437179
Ensembl peptide - ENSP00000436085
Ensembl peptide - ENSP00000435505
Ensembl peptide - ENSP00000435464
Ensembl peptide - ENSP00000435014
Ensembl peptide - ENSP00000434747
Ensembl peptide - ENSP00000433899
Ensembl peptide - ENSP00000433132
Ensembl peptide - ENSP00000433077
Ensembl peptide - ENSP00000372191
Ensembl peptide - ENSP00000432857
NCBI entrez gene - 23410     See in Manteia.
OMIM - 604481
RefSeq - XM_017017431
RefSeq - NM_001017524
RefSeq - NM_012239
RefSeq - XM_005252835
RefSeq - XM_011519956
RefSeq - XM_011519957
RefSeq - XM_017017428
RefSeq - XM_017017429
RefSeq - XM_017017430
RefSeq Peptide - NP_001017524
RefSeq Peptide - NP_036371
swissprot - E9PN58
swissprot - E9PM75
swissprot - E9PM52
swissprot - E9PK80
swissprot - E9PJS6
swissprot - E9PIT6
swissprot - B7WNN4
swissprot - Q9NTG7
swissprot - E9PNA0
swissprot - E9PR48
Ensembl - ENSG00000142082
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt3ENSDARG00000035819Danio rerio
 SIRT3ENSGALG00000032496Gallus gallus
 Sirt3ENSMUSG00000025486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT2 / Q8IXJ6 / sirtuin 2ENSG0000006890338


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR017328  Sirtuin, class I
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006471 protein ADP-ribosylation TAS
 biological_processGO:0006476 protein deacetylation IDA
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0009060 aerobic respiration IMP
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000285441 SOD2 / P04179 / superoxide dismutase 2  / reaction
 ENSG00000182054 IDH2 / P48735 / isocitrate dehydrogenase (NADP(+)) 2, mitochondrial  / reaction
 ENSG00000148672 GLUD1 / P00367 / glutamate dehydrogenase 1  / reaction
 ENSG00000131069 ACSS2 / Q9NR19 / acyl-CoA synthetase short chain family member 2  / reaction






 

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