ENSG00000285441


Homo sapiens

Features
Gene ID: ENSG00000285441
  
Biological name :SOD2
  
Synonyms : P04179 / SOD2 / superoxide dismutase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.3
Gene start: 159679119
Gene end: 159762529
  
Corresponding Affymetrix probe sets: 215223_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442920
NCBI entrez gene - 6648     See in Manteia.
OMIM - 147460
RefSeq - NM_001322820
RefSeq - NM_001322817
RefSeq - NM_001322819
RefSeq Peptide - NP_001309746
RefSeq Peptide - NP_001309748
RefSeq Peptide - NP_001309749
swissprot - P04179
Ensembl - ENSG00000285441
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sod2ENSDARG00000042644Danio rerio
 SOD2ENSGALG00000011661Gallus gallus
 Sod2ENSMUSG00000006818Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOD2 / superoxide dismutase 2ENSG00000112096100


Protein motifs (from Interpro)
Interpro ID Name
 IPR001189  Manganese/iron superoxide dismutase
 IPR019831  Manganese/iron superoxide dismutase, N-terminal
 IPR019832  Manganese/iron superoxide dismutase, C-terminal
 IPR019833  Manganese/iron superoxide dismutase, binding site
 IPR036314  Manganese/iron superoxide dismutase, C-terminal domain superfamily
 IPR036324  Manganese/iron superoxide dismutase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000303 response to superoxide IMP
 biological_processGO:0001315 age-dependent response to reactive oxygen species IMP
 biological_processGO:0001836 release of cytochrome c from mitochondria ISS
 biological_processGO:0003069 acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006801 superoxide metabolic process IDA
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0019430 removal of superoxide radicals IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032364 oxygen homeostasis IMP
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0051289 protein homotetramerization IPI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004784 superoxide dismutase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0030145 manganese ion binding TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142082 SIRT3 / Q9NTG7 / sirtuin 3  / reaction
 ENSG00000285441 SOD2 / P04179 / superoxide dismutase 2  / complex






 

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