ENSMUSG00000006818


Mus musculus

Features
Gene ID: ENSMUSG00000006818
  
Biological name :Sod2
  
Synonyms : P09671 / Sod2 / superoxide dismutase 2, mitochondrial
  
Possible biological names infered from orthology : P04179 / superoxide dismutase 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 13007839
Gene end: 13018119
  
Corresponding Affymetrix probe sets: 10441815 (MoGene1.0st)   1417193_at (Mouse Genome 430 2.0 Array)   1417194_at (Mouse Genome 430 2.0 Array)   1448610_a_at (Mouse Genome 430 2.0 Array)   1454976_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007012
NCBI entrez gene - 20656     See in Manteia.
MGI - MGI:98352
RefSeq - NM_013671
RefSeq Peptide - NP_038699
swissprot - P09671
swissprot - Q4FJX9
Ensembl - ENSMUSG00000006818
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sod2ENSDARG00000042644Danio rerio
 SOD2ENSGALG00000011661Gallus gallus
 SOD2ENSG00000285441Homo sapiens
 SOD2ENSG00000112096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001189  Manganese/iron superoxide dismutase
 IPR019831  Manganese/iron superoxide dismutase, N-terminal
 IPR019832  Manganese/iron superoxide dismutase, C-terminal
 IPR019833  Manganese/iron superoxide dismutase, binding site
 IPR036314  Manganese/iron superoxide dismutase, C-terminal domain superfamily
 IPR036324  Manganese/iron superoxide dismutase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IMP
 biological_processGO:0000303 response to superoxide ISO
 biological_processGO:0001306 age-dependent response to oxidative stress IMP
 biological_processGO:0001315 age-dependent response to reactive oxygen species ISO
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0003032 detection of oxygen IMP
 biological_processGO:0003069 acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0006801 superoxide metabolic process ISO
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0008637 apoptotic mitochondrial changes IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010042 response to manganese ion IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010269 response to selenium ion IEA
 biological_processGO:0010332 response to gamma radiation IGI
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032364 oxygen homeostasis ISO
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033591 response to L-ascorbic acid IEA
 biological_processGO:0034021 response to silicon dioxide IEA
 biological_processGO:0035900 response to isolation stress IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042554 superoxide anion generation IMP
 biological_processGO:0042743 hydrogen peroxide metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IDA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048678 response to axon injury IMP
 biological_processGO:0048773 erythrophore differentiation IMP
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0050790 regulation of catalytic activity IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:0055093 response to hyperoxia IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071000 response to magnetism IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004784 superoxide dismutase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IMP
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ath38CAST/Ei/Ath38CAST/Ei,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: CAST/Ei * C57BL/6J

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0000906 abnormal mesencephalic trigeminal nucleus "malformation or disorganization of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000911 abnormal trigeminal motor nucleus morphology "malformation or disorganization of the group of motor neurons innervating the muscles of mastication" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Gys2tm1.1Arte/Gys2tm1.1Arte
Genetic Background: Not Specified

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Dhm/Ryr1tm1.1Dhm
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0002319 hyperoxia "elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002329 abnormal blood gas "anomaly in the amount of oxygen and carbon dioxide in the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003027 abnormal blood pH regulation "anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion" [RGD:Rat Genome Database submission, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003032 hypocapnia "reduced concentration of CO2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003061 decreased aerobic running capacity "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0003083 abnormal tibialis anterior morphology "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gys2tm1.1Arte/Gys2tm1.1Arte
Genetic Background: Not Specified

 MP:0003195 calcinosis "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

Allelic Composition: Sod2tm1Shs/Sod2+,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: involves: C57BL/6J * CD-1

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0005113 decreased number of anterior horn cells "fewer than the expected number of cells in the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0006185 retinal hemorrhage "bleeding into the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Kskk/Sod2tm1Kskk,Tg(BEST1-rtTA,tetO-cre)1Yzl/0
Genetic Background: B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009051 dilated distal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

Allelic Composition: Sod2tm1Shs/Sod2+,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0010028 aciduria "excretion of an acid urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010630 abnormal cardiac muscle tissue morphology "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Gys2tm1.1Arte/Gys2tm1.1Arte
Genetic Background: Not Specified

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod2tm1.1Kskk/Sod2tm1.1Kskk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje,SvtmsC57BL/6J/SvtmsC57BL/6J
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Sod2tm1(tetO-Sod2)Evbo/Sod2tm1(tetO-Sod2)Evbo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nr2e1tm1Rtyu/Nr2e1tm1Rtyu
Genetic Background: Not Specified

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: C57BL/6 * C57BL/6CrSlc

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0011687 decreased epidermal stem cell number "a reduction in the number of somatic stem cells that are part of the epidermis" [CL:1000428, MGI:csmith]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Sod2tm1Cje/Sod2+
Genetic Background: B6.Cg-Sod2tm1Cje/Mmmh

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: D2.Cg-Sod2tm1Cje

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Gys2tm1.1Arte/Gys2tm1.1Arte
Genetic Background: Not Specified

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Sod2tm1Cje/Sod2tm1Cje
Genetic Background: involves: C57BL/6J * CD-1

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6CrSlc * FVB

 MP:0020543 decreased substantia nigra size "decreased size of the substantia nigra" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm1(NOTCH3)Sat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(TNNI2-icre)1Vrmn/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006818 Sod2 / P09671 / superoxide dismutase 2, mitochondrial / P04179* / superoxide dismutase 2*  / complex
 ENSMUSG00000025486 Sirt3 / Q8R104 / sirtuin 3 / Q9NTG7*  / reaction






 

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