ENSGALG00000029761


Gallus gallus

Features
Gene ID: ENSGALG00000029761
  
Biological name :SIRT2
  
Synonyms : NAD-dependent protein deacetylase sirtuin-2 / SIRT2
  
Possible biological names infered from orthology : Q8IXJ6 / Q8VDQ8 / sirtuin 2
  
Species: Gallus gallus
  
Chr. number: 32
Strand: -1
Band:
Gene start: 72756
Gene end: 75383
  
Corresponding Affymetrix probe sets: Gga.7024.1.S1_s_at (Chicken Array)   GgaAffx.12953.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044776
Ensembl peptide - ENSGALP00000052275
NCBI entrez gene - 548628     See in Manteia.
RefSeq - NM_001017414
RefSeq - XM_015300224
RefSeq - XM_015300225
RefSeq Peptide - NP_001017414
swissprot - A0A1D5PHJ5
swissprot - A0A1D5NWN5
Ensembl - ENSGALG00000029761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt2ENSDARG00000011488Danio rerio
 SIRT2ENSG00000068903Homo sapiens
 Sirt2ENSMUSG00000015149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT3 / sirtuin 3 / Q8R104* / Q9NTG7*ENSGALG0000003249637


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006476 protein deacetylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016575 histone deacetylation IEA
 biological_processGO:0022011 myelination in peripheral nervous system IEA
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034983 peptidyl-lysine deacetylation IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0044242 cellular lipid catabolic process IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045836 positive regulation of meiotic nuclear division IEA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0061433 cellular response to caloric restriction IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0090042 tubulin deacetylation IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 biological_processGO:1900195 positive regulation of oocyte maturation IEA
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1900425 negative regulation of defense response to bacterium IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0033010 paranodal junction IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0072687 meiotic spindle IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004407 histone deacetylase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017136 NAD-dependent histone deacetylase activity IEA
 molecular_functionGO:0033558 protein deacetylase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0042903 tubulin deacetylase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) IEA
 molecular_functionGO:0070403 NAD+ binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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