ENSG00000182890


Homo sapiens

Features
Gene ID: ENSG00000182890
  
Biological name :GLUD2
  
Synonyms : GLUD2 / glutamate dehydrogenase 2 / P49448
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q24
Gene start: 121047588
Gene end: 121050080
  
Corresponding Affymetrix probe sets: 210447_at (Human Genome U133 Plus 2.0 Array)   215794_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000327589
NCBI entrez gene - 2747     See in Manteia.
OMIM - 300144
RefSeq - NM_012084
RefSeq Peptide - NP_036216
swissprot - A0A140VK14
swissprot - P49448
Ensembl - ENSG00000182890
  
Related genetic diseases (OMIM): 168600 - {Parkinson disease, age of onset, modifier}, 168600
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glud1aENSDARG00000008816Danio rerio
 glud1bENSDARG00000101074Danio rerio
 ENSGALG00000034735Gallus gallus
 Glud1ENSMUSG00000021794Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLUD1 / P00367 / glutamate dehydrogenase 1ENSG0000014867290


Protein motifs (from Interpro)
Interpro ID Name
 IPR006095  Glutamate/phenylalanine/leucine/valine dehydrogenase
 IPR006096  Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal
 IPR006097  Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain
 IPR033524  Leu/Phe/Val dehydrogenases active site
 IPR033922  NAD(P) binding domain of glutamate dehydrogenase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006536 glutamate metabolic process IDA
 biological_processGO:0006537 glutamate biosynthetic process IDA
 biological_processGO:0006538 glutamate catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IDA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0004352 glutamate dehydrogenase (NAD+) activity IDA
 molecular_functionGO:0004353 glutamate dehydrogenase [NAD(P)+] activity IDA
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0043531 ADP binding IDA
 molecular_functionGO:0070728 leucine binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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