ENSMUSG00000054021


Mus musculus

Features
Gene ID: ENSMUSG00000054021
  
Biological name :Sirt5
  
Synonyms : NAD-dependent protein deacylase sirtuin-5, mitochondrial / Q8K2C6 / Sirt5
  
Possible biological names infered from orthology : Q9NXA8 / sirtuin 5
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A4
Gene start: 43365496
Gene end: 43395203
  
Corresponding Affymetrix probe sets: 10404815 (MoGene1.0st)   1428915_at (Mouse Genome 430 2.0 Array)   1428916_s_at (Mouse Genome 430 2.0 Array)   1432105_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152640
Ensembl peptide - ENSMUSP00000152796
Ensembl peptide - ENSMUSP00000152763
Ensembl peptide - ENSMUSP00000152760
Ensembl peptide - ENSMUSP00000152740
Ensembl peptide - ENSMUSP00000152668
Ensembl peptide - ENSMUSP00000071048
Ensembl peptide - ENSMUSP00000152526
NCBI entrez gene - 68346     See in Manteia.
MGI - MGI:1915596
RefSeq - XM_011244413
RefSeq - XM_011244412
RefSeq - XM_006516954
RefSeq - XM_006516953
RefSeq - NM_178848
RefSeq - XM_006516951
RefSeq - XM_006516952
RefSeq Peptide - NP_849179
swissprot - Q8K2C6
swissprot - A0A1Y7VNW0
swissprot - A0A1Y7VJY8
swissprot - A0A1Y7VK33
swissprot - A0A1Y7VM56
swissprot - A0A1Y7VMJ7
Ensembl - ENSMUSG00000054021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt5ENSDARG00000039684Danio rerio
 SIRT5ENSGALG00000012692Gallus gallus
 SIRT5ENSG00000124523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sirt4 / Q8R216 / NAD-dependent protein lipoamidase sirtuin-4, mitochondrial / Q9Y6E7* / sirtuin 4*ENSMUSG0000002952425
Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*ENSMUSG0000002006323


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR026591  Sirtuin, catalytic core small domain superfamily
 IPR027546  Sirtuin, class III
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006476 protein deacetylation ISS
 biological_processGO:0010566 regulation of ketone biosynthetic process IMP
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0036046 protein demalonylation IDA
 biological_processGO:0036047 peptidyl-lysine demalonylation IMP
 biological_processGO:0036048 protein desuccinylation IMP
 biological_processGO:0036049 peptidyl-lysine desuccinylation IMP
 biological_processGO:0061698 protein deglutarylation IDA
 biological_processGO:0061699 peptidyl-lysine deglutarylation IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process ISO
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity IEA
 molecular_functionGO:0036054 protein-malonyllysine demalonylase activity ISO
 molecular_functionGO:0036055 protein-succinyllysine desuccinylase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061697 protein-glutaryllysine deglutarylase activity IDA
 molecular_functionGO:0070403 NAD+ binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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