ENSG00000124523


Homo sapiens

Features
Gene ID: ENSG00000124523
  
Biological name :SIRT5
  
Synonyms : Q9NXA8 / SIRT5 / sirtuin 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p23
Gene start: 13574529
Gene end: 13615158
  
Corresponding Affymetrix probe sets: 1569938_at (Human Genome U133 Plus 2.0 Array)   219185_at (Human Genome U133 Plus 2.0 Array)   221010_s_at (Human Genome U133 Plus 2.0 Array)   229112_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476211
Ensembl peptide - ENSP00000380509
Ensembl peptide - ENSP00000476228
Ensembl peptide - ENSP00000352830
Ensembl peptide - ENSP00000368552
Ensembl peptide - ENSP00000368564
NCBI entrez gene - 23408     See in Manteia.
OMIM - 604483
RefSeq - XM_017010625
RefSeq - NM_001193267
RefSeq - NM_001242827
RefSeq - NM_012241
RefSeq - NM_031244
RefSeq - XM_005248968
RefSeq - XM_011514444
RefSeq - XM_017010620
RefSeq - XM_017010621
RefSeq - XM_017010622
RefSeq - XM_017010623
RefSeq - XM_017010624
RefSeq Peptide - NP_112534
RefSeq Peptide - NP_001180196
RefSeq Peptide - NP_001229756
RefSeq Peptide - NP_036373
swissprot - U3KQT8
swissprot - Q7Z3A0
swissprot - Q9NXA8
swissprot - A0A024R012
Ensembl - ENSG00000124523
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sirt5ENSDARG00000039684Danio rerio
 SIRT5ENSGALG00000012692Gallus gallus
 Sirt5ENSMUSG00000054021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIRT1 / Q96EB6 / sirtuin 1ENSG0000009671725
SIRT4 / Q9Y6E7 / sirtuin 4ENSG0000008916325


Protein motifs (from Interpro)
Interpro ID Name
 IPR003000  Sirtuin family
 IPR026590  Sirtuin family, catalytic core domain
 IPR027546  Sirtuin, class III
 IPR029035  DHS-like NAD/FAD-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing TAS
 biological_processGO:0006471 protein ADP-ribosylation TAS
 biological_processGO:0006476 protein deacetylation IDA
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0010566 regulation of ketone biosynthetic process ISS
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0036046 protein demalonylation IDA
 biological_processGO:0036047 peptidyl-lysine demalonylation IDA
 biological_processGO:0036048 protein desuccinylation IDA
 biological_processGO:0036049 peptidyl-lysine desuccinylation IDA
 biological_processGO:0061698 protein deglutarylation IDA
 biological_processGO:0061699 peptidyl-lysine deglutarylation IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity TAS
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034979 NAD-dependent protein deacetylase activity TAS
 molecular_functionGO:0036054 protein-malonyllysine demalonylase activity IDA
 molecular_functionGO:0036055 protein-succinyllysine desuccinylase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061697 protein-glutaryllysine deglutarylase activity IDA
 molecular_functionGO:0070403 NAD+ binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172115 CYCS / P99999 / cytochrome c, somatic  / reaction






 

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