ENSG00000172115


Homo sapiens

Features
Gene ID: ENSG00000172115
  
Biological name :CYCS
  
Synonyms : CYCS / cytochrome c, somatic / P99999
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p15.3
Gene start: 25120091
Gene end: 25125361
  
Corresponding Affymetrix probe sets: 208905_at (Human Genome U133 Plus 2.0 Array)   229415_at (Human Genome U133 Plus 2.0 Array)   244546_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387279
Ensembl peptide - ENSP00000416479
Ensembl peptide - ENSP00000307786
Ensembl peptide - ENSP00000386270
NCBI entrez gene - 54205     See in Manteia.
OMIM - 123970
RefSeq - NM_018947
RefSeq Peptide - NP_061820
swissprot - C9JFR7
swissprot - G4XXL9
swissprot - P99999
Ensembl - ENSG00000172115
  
Related genetic diseases (OMIM): 612004 - Thrombocytopenia 4, 612004
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cycsaENSDARG00000095636Danio rerio
 CYCSENSGALG00000011020Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002327  Cytochrome c, class IA/ IB
 IPR009056  Cytochrome c-like domain
 IPR036909  Cytochrome c-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c TAS
 biological_processGO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0045333 cellular respiration TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0000159 protein phosphatase type 2A complex TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005758 mitochondrial intermembrane space IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070469 respiratory chain IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Respiratory electron transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001873 Thrombocytopenia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120868 APAF1 / O14727 / apoptotic peptidase activating factor 1  / reaction / complex
 ENSG00000132906 CASP9 / P55211 / caspase 9  / complex / reaction
 ENSG00000172115 CYCS / P99999 / cytochrome c, somatic  / reaction
 ENSG00000124523 SIRT5 / Q9NXA8 / sirtuin 5  / reaction






 

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